Evidence map›Paper›PMID 37103240›Full record

ArticleJournal of the American Chemical Society2023

Visualizing Cardiolipin In Situ with HKCL-1M, a Highly Selective and Sensitive Fluorescent Probe.

Wei Wang, Nai-Kei Wong, Siu-Lun Bok, You Xu, Yang Guo, Lu Xu, Meiling Zuo, Claudette M St Croix, Gaowei Mao, Alexandr Kapralov and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 24 citations in OpenAlex.

  1. Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Wei WangGuangdong Provincial Key Laboratory of Optical Fiber Sensing and Communication, Institute of Photonics Technology, Jinan University, Guangzhou 510632, China.ORCID 0000-0003-2950-9882
Nai-Kei WongClinical Pharmacology Section, Department of Pharmacology, Shantou University Medical College, Shantou 515041, China.
Siu-Lun BokMorningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Hong Kong 999077, China.
You XuKey Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou 310024, China.
Yang GuoQingdao Institute for Theoretical and Computational Sciences, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, China.ORCID 0000-0003-2177-8463
Lu XuSchool of Life Sciences, Westlake University, Hangzhou 310024, China.
Meiling ZuoSchool of Life Sciences, Westlake University, Hangzhou 310024, China.
Claudette M St CroixDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Gaowei MaoDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Alexandr KapralovDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.
Hülya BayirCenter for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0003-2361-4120
Valerian E KaganDepartment of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15219, United States.ORCID 0000-0002-7245-1885
Dan YangMorningside Laboratory for Chemical Biology, Department of Chemistry, The University of Hong Kong, Hong Kong 999077, China.ORCID 0000-0002-1726-9335
University of Pittsburgh · USWestlake University · CNJinan University · CNShandong University · CNShantou University · CNUniversity of Hong Kong · HK

Funding

Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8M
NINDS NIH HHS R01 NS076511
6 · The paper itself

Abstract

Reliable probing of cardiolipin (CL) content in dynamic cellular milieux presents significant challenges and great opportunities for understanding mitochondria-related diseases, including cancer, neurodegeneration, and diabetes mellitus. In intact respiring cells, selectivity and sensitivity for CL detection are technically demanding due to structural similarities among phospholipids and compartmental secludedness of the inner mitochondrial membrane. Here, we report a novel "turn-on" fluorescent probe

Indexed as

CardiolipinsFluorescent DyesMitochondriaMitochondrial MembranesPhospholipidsCardiolipinsFluorescent DyesPhospholipids

Identifiers

PMID37103240
PMCPMC10214440
OpenAlexW4367174971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.