Evidence map›Paper›PMID 37103114›Full record

ArticleIn vivo (Athens, Greece)

Rosuvastatin Attenuates Progression of Atherosclerosis and Reduces Serum IL6 and CCL2 Levels in Apolipoprotein-E-deficient Mice.

Diamantis I Tsilimigras, Kalliopi Thanopoulou, Maria Salagianni, Gerasimos Siasos, Evangelos Oikonomou, Despina D Perrea, Nikolaos Nirakis, Konstantinos Filis, Konstantinos Tsioufis, Dimitrios Tousoulis and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Impact of DPP-4 Inhibitors on Interleukin Levels in Type 2 Diabetes Mellitus.The Journal of clinical endocrinology and metabolism · 2025
    Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Impact ofFrontiers in gastroenterology (Lausanne, Switzerland) · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Diamantis I TsilimigrasDivision of Vascular Surgery, First Propedeutic Department of Surgery, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece; diamantis.tsilimigras@gmail.com.
Kalliopi ThanopoulouClinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Maria SalagianniClinical, Experimental Surgery and Translational Research Center, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.
Gerasimos SiasosFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Evangelos OikonomouFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Despina D PerreaN.S. Christeas Laboratory for Experimental Surgery and Surgical Research National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos NirakisDivision of Vascular Surgery, First Propedeutic Department of Surgery, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos FilisDivision of Vascular Surgery, First Propedeutic Department of Surgery, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos TsioufisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Dimitrios TousoulisFirst Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
Fragiska SigalaDivision of Vascular Surgery, First Propedeutic Department of Surgery, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GRBiomedical Research Foundation of the Academy of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimApolipoprotein E-deficient (Apoe MATERIALS AND

methodsEighteen Apoe

resultsThe lipidemic profile of Apoe

conclusionSerum IL6 and CCL2 levels might potentially be used as clinical markers of progression of atherosclerosis during statin treatment for hypercholesterolemia.

Indexed as

AtherosclerosisHydroxymethylglutaryl-CoA Reductase InhibitorsPlaque, AtheroscleroticAnimalsApolipoproteinsApolipoproteins EAzo CompoundsChemokine CCL2ChemokinesDiet, High-FatHumansInterleukin-6LigandsLipidsMiceMice, Inbred C57BLApolipoproteinsApolipoproteins EAzo CompoundsCCL2 protein, humanCcl2 protein, mouseChemokine CCL2ChemokinesHydroxymethylglutaryl-CoA Reductase InhibitorsInterleukin-6interleukin-6, mouseLigandsLipidsoil red ORosuvastatin CalciumScarlet RedTumor Necrosis Factor-alphaAPOEatherosclerosisCCL2IL6mouseRosuvastatin

Identifiers

PMID37103114
PMCPMC10188013
OpenAlexW4367175255

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.