Evidence map›Paper›PMID 37103110›Full record

ArticleIn vivo (Athens, Greece)

Induction Therapy With Cisplatin, 5-Fluorouracil, Leucovorin, and Paclitaxel in Patients With Head and Neck Cancer.

Carlos Eduardo Coelho DE Sa, Daniel DE Iracema Gomes Cubero, Rafael Everton Assuncao Ribeiro DA Costa, Renato DI Pardo, Felipe Jose Silva Melo Cruz, Cláudia Vaz DE Melo Sette, Eliana Araujo DA Silva, Auro Del Giglio

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Carlos Eduardo Coelho DE SaOncology Department, Oncocenter, Teresina, PI, Brazil.
Daniel DE Iracema Gomes CuberoOncology Department, ABC School of Medicine, Santo André, SP, Brazil.
Rafael Everton Assuncao Ribeiro DA CostaCenter for Health Sciences, State University of Piauí, Teresina, PI, Brazil; rafaelearcosta@gmail.com.
Renato DI PardoOncology Department, Santa Marcelina Hospital, São Paulo, SP, Brazil.
Felipe Jose Silva Melo CruzOncology Department, ABC School of Medicine, Santo André, SP, Brazil.
Cláudia Vaz DE Melo SetteOncology Department, ABC School of Medicine, Santo André, SP, Brazil.
Eliana Araujo DA SilvaOncology Department, ABC School of Medicine, Santo André, SP, Brazil.
Auro Del GiglioOncology Department, ABC School of Medicine, Santo André, SP, Brazil.
Faculdade de Medicina do ABC · BRHospital Santa Marcelina · BRUniversidade Estadual do Piau · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis study aimed to evaluate the toxicities and response rate of a modified TPF (docetaxel, cisplatin, and 5-fluorouracil) protocol in patients with locally advanced head and neck cancer (ECOG performance status ≤1). PATIENTS AND

methodsInduction treatment consisted of cisplatin 25 mg/m

resultsThe main toxicities were grade 1 neuropathy, mucositis, and fatigue. There were four episodes of severe toxicities (grade ≥3). There was one early death, and 2 patients were discontinued due to hematological toxicity. Other side effects included neutropenia, nausea, diarrhea, and vomiting.

conclusionInduction therapy with cisplatin, 5-fluorouracil, leucovorin, and paclitaxel in head and neck cancer is not feasible because of severe toxicity.

Indexed as

FluorouracilHead and Neck NeoplasmsAntineoplastic Combined Chemotherapy ProtocolsCisplatinHumansInduction ChemotherapyLeucovorinPaclitaxelCisplatinFluorouracilLeucovorinPaclitaxelantineoplastic agentsbone marrowHead and neck cancerquality of lifetoxicity

Identifiers

PMID37103110
PMCPMC10188017
OpenAlexW4367174190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.