Evidence map›Paper›PMID 37103084›Full record

ArticleIn vivo (Athens, Greece)

Therapy Guidance by Vaginal Smears of Pregnant Women With Preterm Complications in Correlation With Maternal and Neonatal Outcome: A Retrospective Analysis.

Stefan Stefanovic, Eva Werner, Marlis Gerigk, Ralph Hornung, Uros Karic, Christel WEIß, Benjamin Tuschy, Sebastian Berlit, Marc Sütterlin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Stefan StefanovicDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany; stefan.stefanovic@umm.de.
Eva WernerDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Marlis GerigkInstitute of Medical Microbiology and Hygiene, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Ralph HornungDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Uros KaricUniversity Hospital for Infectious and Tropical Diseases, Belgrade University School of Medicine, Belgrade, Serbia.
Christel WEIßDepartment of Medical Statistics and Biomathematics, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Benjamin TuschyDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Sebastian BerlitDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Marc SütterlinDepartment of Gynecology and Obstetrics, University Medical Center Mannheim, Heidelberg University, Mannheim, Germany.
Heidelberg University · DEUniversity Hospital Heidelberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimThis retrospective cohort study enrolled hospitalized women with 24+0 to 33+6 gestational weeks with conditions associated with preterm birth. We evaluated the ability of vaginal swab isolates to guide antibiotic management decisions in the setting of threatened preterm towards a clinical advantage, i.e., longer delay between diagnosis and birth, better neonatal outcomes. PATIENTS AND

methodsVaginal swabs were obtained from all patients and antibiotic resistance profiles determined in case of growth. The cohort was divided into two groups: the antibiogram-noncongruently managed Group 1 and the antibiogram-congruently managed Group 2. These groups were compared in regard to multiple maternal and neonatal endpoints.

resultsIn total, 698 cases were analyzed - 224 in Group 1 and 474 in Group 2. Antibiotics were ordered/continued by the treating physician in 138 cases (138/698; 19.8%) upon review of vaginal swab cultures results. Forty-five among them (32.6%) received antibiotics inactive against the isolated bacteria. 335 (25.4%) patients had only normal vaginal flora, and 95.6% of them had not received antibiotics. Facultatively pathogenic microorganisms were isolated in 52% patients. Only 5% of the neonates had bacterial isolates identical to those of their mothers. There were no significant differences in outcomes between Group 1 and Group 2.

conclusionNo association was found between a swab-result-guided antibiotic management protocol and maternal or fetal outcome in the setting of preterm birth risk between 24 and 34 gestational weeks. These findings underline the importance of critical rethinking the frequency of vaginal smears and fine-tuning the indications for antibiotic treatment.

Indexed as

Pregnant PeoplePremature BirthAnti-Bacterial AgentsFemaleHumansInfant, NewbornPregnancyRetrospective StudiesVaginal SmearsAnti-Bacterial Agentsneonatal outcomePregnancypreterm complicationsvaginal smears

Identifiers

PMID37103084
PMCPMC10188051
OpenAlexW4367174322

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.