Evidence map›Paper›PMID 37103067›Full record

ArticleIn vivo (Athens, Greece)

A Pilot Study of the Association

Angeliki Chorti, Charoula Achilla, Despoina Tsalkatidou, Moysis Moysidis, Angeliki Cheva, Anthoula Chatzikyriakidou, Theodosios Papavramidis

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. A Pilot Study ofBalkan journal of medical genetics : BJMG · 2024
    Article
  3. Association ofGenes · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Angeliki Chorti *First Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Charoula Achilla *Laboratory of Medical Biology - Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Despoina TsalkatidouFirst Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Moysis MoysidisFirst Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Angeliki ChevaLaboratory of General Pathology & Pathological Anatomy, Department of Pathology, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
Anthoula Chatzikyriakidou *Laboratory of Medical Biology - Genetics, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece; chatzikyra@auth.gr.
Theodosios Papavramidis *First Propedeutic Department of Surgery, AHEPA University Hospital, Faculty of Medicine, School of Health Sciences, Aristotle University, Thessaloniki, Greece.
AHEPA University Hospital · GRAristotle University of Thessaloniki · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimPrimary hyperparathyroidism (PHPT) is the third most common endocrine disorder characterized by autonomous parathyroid hormone (PTH) production from one or more parathyroid glands and hypocalcemia. Vitamin D through its receptor is a principal regulator of parathyroid glands function. VDR gene polymorphisms, which affect the expression or structure of VDR protein, may be involved in the genetic pathogenesis of PHPT. The aim of this study was to investigate the role of FokI, ApaI, TaqI, and BsmI VDR gene polymorphisms as genetic predisposing factors for PHPT. PATIENTS AND

methodsFifty unrelated patients with sporadic PHPT and an equal number of corresponding ethnicity, sex and age range healthy volunteers were enrolled in the study. Genotyping was performed with polymerase chain reaction and restriction fragment length polymorphism assay.

resultsStatistically significant difference was observed in TaqI genotype distribution between PHPT patients and controls, while no association was detected for the other studied polymorphisms.

conclusionTaqI TT and TC genotypes may be associated with PHPT risk in Greek population. Further independent studies are needed to replicate and validate the role of VDR TaqI polymorphism in PHPT predisposition.

Indexed as

Genetic Predisposition to DiseaseHyperparathyroidism, PrimaryCase-Control StudiesGenotypeHumansPilot ProjectsPolymorphism, GeneticPolymorphism, Single NucleotideReceptors, CalcitriolReceptors, CalcitriolVDR protein, humanApaIBsmIFokIpolymorphismPrimary hyperparathyroidismTaqIvitamin D receptor

Identifiers

PMID37103067
PMCPMC10188045
OpenAlexW4367174542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.