Evidence map›Paper›PMID 37103040›Full record

ArticleJournal of cardiovascular development and disease2023

Purkinje Cardiomyocytes of the Adult Ventricular Conduction System Are Highly Diploid but Not Uniquely Regenerative.

Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C Westbury, Kristie D Cox, Kelsey Tjen, Ruolan Song, Glenn I Fishman, Takako Makita, Henry M Sucov

Open access · goldAbstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. A kinase-dead natural polymorphism in the caninemicroPublication biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Hirofumi WatanabeDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Ge TaoDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Peiheng GanDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0001-8617-0606
Baylee C WestburyDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Kristie D CoxDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Kelsey TjenDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Ruolan SongDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.
Glenn I FishmanLeon H. Charney Division of Cardiology, New York University Grossman School of Medicine, New York, NY 10016, USA.
Takako MakitaDarby Children's Research Institute, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA.
Henry M SucovDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC 29425, USA.ORCID 0000-0002-3792-3795
Medical University of South Carolina · USNew York University · US

Funding

Purkinje Cells and Arrhythmia MechanismsR01HL105983 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FISHMAN, GLENN I · 2011 to 2019
$5.2M
The complex genetics of heart regenerationR01HL144938 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SUCOV, HENRY M · 2019 to 2025
$3.4M
The role of Pitx2 in heart injury and regeneration.R01HL148728 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TAO, GE · 2020 to 2024
$1.9M
NHLBI NIH HHS R01 HL105983NHLBI NIH HHS R01 HL144938NHLBI NIH HHS R01 HL148728NIH HHS HL144938
6 · The paper itself

Abstract

Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify. Diploid CMs are a candidate cell type that may have unique proliferative and regenerative competence, but no molecular markers are yet known that selectively identify all or subpopulations of diploid CMs. Here, using the conduction system expression marker Cntn2-GFP and the conduction system lineage marker Etv1Cre

Indexed as

conduction systemdiploid cardiomyocyteheart regenerationpolyploidyPurkinje cell

Identifiers

PMID37103040
PMCPMC10140853
OpenAlexW4362698671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.