Evidence map›Paper›PMID 37102947›Full record

ArticleGels (Basel, Switzerland)2023

Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels.

Chenghong Huang, Hong Tang, Xiaorong Huang, Hongjie Chen, Kang Yang, Qi Yin, Lin Zhang, Xia Li, Xue Mou, Shuangkou Chen and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chenghong HuangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.ORCID 0000-0003-2754-2523
Hong TangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Xiaorong HuangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Hongjie ChenSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Kang YangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Qi YinSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Lin ZhangSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Xia LiSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Xue MouSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Shuangkou ChenSchool of Chemistry and Chemical Engineering, Chongqing University of Science and Technology, Chongqing 401331, China.
Yuchan ZhangInstitute of Life Science, And Laboratory of Tissue and Cell Biology, Lab Teaching & Management Center, Chongqing Medical University, Chongqing 400016, China.
Yan HuTuberculosis Reference Laboratory, Chongqing Tuberculosis Control Institute, Chongqing 400050, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymer gels are usually used for crystal growth as the recovered crystals have better properties. Fast crystallization under nanoscale confinement holds great benefits, especially in polymer microgels as its tunable microstructures. This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. It found that EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration less than 1:0.8. It was observed that EVA crystal growth has two models involving hang-wall growth at the air-liquid interface at the contact line, as well as extrude-bubble growth at any sites on the liquid surface. Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs.

Indexed as

CMCScrystallizationEVAnanoconfinement

Identifiers

PMID37102947
PMCPMC10138138

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.