Evidence map›Paper›PMID 37102869›Full record

ArticleMicrobiology spectrum2023

A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying

Siquan Shen, Renru Han, Dandan Yin, Bo Jiang, Li Ding, Yan Guo, Shi Wu, Chuning Wang, Hong Zhang, Fupin Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Mapping Antimicrobial Resistance inDiagnostics (Basel, Switzerland) · 2025
    Article
  2. Characterization of OXA232-Producing Carbapenem-ResistantPolish journal of microbiology · 2025
    Article
  3. Hypervirulent Capsular Serotypes K1 and K2International journal of molecular sciences · 2024
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Siquan Shen *Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Renru Han *Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Dandan YinInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Bo JiangDepartment of Clinical Laboratory, First Affiliated Hospital of Kunming Medical University, Kunming, China.
Li DingInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Yan GuoInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Shi WuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Chuning WangInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.
Hong ZhangDepartment of Clinical Laboratory, Shanghai Children's Hospital, Shanghai Jiaotong University, Shanghai, China.ORCID 0000-0002-0886-9531
Fupin HuInstitute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.ORCID 0000-0002-4493-0619
Fudan University · CNKunming Medical University · CNShanghai Children's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

OXA-232 carbapenemase is becoming a threat in China due to its high prevalence, mortality, and limited treatment options. However, little information is available on the impact of OXA-232-producing Klebsiella pneumoniae in China. This study aims to characterize the clonal relationships, the genetic mechanisms of resistance, and the virulence of OXA-232-producing K. pneumoniae isolates in China. We collected 81 OXA-232-producing K. pneumoniae clinical isolates from 2017 to 2021. Antimicrobial susceptibility testing was performed using the broth microdilution method. Capsular types, multilocus sequence types, virulence genes, antimicrobial resistance (AMR) determinants, plasmid replicon types, and single-nucleotide polymorphism (SNP) phylogeny were inferred from whole-genome sequences. OXA-232-producing K. pneumoniae strains were resistant to most antimicrobial agents. These isolates showed partial differences in susceptibility to carbapenems: all strains were resistant to ertapenem, while the resistance rates to imipenem and meropenem were 67.9% and 97.5%, respectively. Sequencing and capsular diversity analysis of the 81 K. pneumoniae isolates revealed 3 sequence types (ST15, ST231, and one novel ST [ST-V]), 2 K-locus types (KL112 and KL51), and 2 O-locus types (O2V1 and O2V2). The predominant plasmid replicon types associated with the OXA-232 and

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsGenomicsHumansMeropenemMicrobial Sensitivity TestsPlasmidsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsMeropenemblaOXA-232genetic contextgenetic environmentKlebsiella pneumoniaermtF

Identifiers

PMID37102869
PMCPMC10269757
OpenAlexW4367174598

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.