ArticleDevelopment (Cambridge, England)2023
Evidence implicating sequential commitment of the founder lineages in the human blastocyst by order of hypoblast gene activation.
Article in Development (Cambridge, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Stem cell-based embryo models as a tool for reproductive biology.Molecular human reproduction · 2026Review
- Amniogenesis in embryos and stem cell models.Nature cell biology · 2026Review
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- Review
- An inducible model of human post-implantation development derived from primed and naive stem cells.Cell stem cell · 2025Article
- Suppression of ERK signalling promotes pluripotent epiblast in the human blastocyst.Nature communications · 2025Article
- Pluripotent cell states and fates in human embryo models.Development (Cambridge, England) · 2025Review
- Divergent destinies: insights into the molecular mechanisms underlying EPI and PE fate determination.Life science alliance · 2025Review
- Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness.Nature cell biology · 2025Article
- Early human development and stem cell-based human embryo models.Cell stem cell · 2024Review
- Branching topology of the human embryo transcriptome revealed by Entropy Sort Feature Weighting.Development (Cambridge, England) · 2024Article
- Self-renewing human naïve pluripotent stem cells dedifferentiate in 3D culture and form blastoids spontaneously.Nature communications · 2024Article
- The human embryo selection arena is associated with transposable element activity.PLoS biology · 2023Article
- Bovine blastocyst-like structures derived from stem cell cultures.Cell stem cell · 2023Article
- Dissecting Human Embryogenesis With Blastoids: Insights Into Lineage Specification and Early Development.Reproductive medicine and biologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Successful human pregnancy depends upon rapid establishment of three founder lineages: the trophectoderm, epiblast and hypoblast, which together form the blastocyst. Each plays an essential role in preparing the embryo for implantation and subsequent development. Several models have been proposed to define the lineage segregation. One suggests that all lineages specify simultaneously; another favours the differentiation of the trophectoderm before separation of the epiblast and hypoblast, either via differentiation of the hypoblast from the established epiblast, or production of both tissues from the inner cell mass precursor. To begin to resolve this discrepancy and thereby understand the sequential process for production of viable human embryos, we investigated the expression order of genes associated with emergence of hypoblast. Based upon published data and immunofluorescence analysis for candidate genes, we present a basic blueprint for human hypoblast differentiation, lending support to the proposed model of sequential segregation of the founder lineages of the human blastocyst. The first characterised marker, specific initially to the early inner cell mass, and subsequently identifying presumptive hypoblast, is PDGFRA, followed by SOX17, FOXA2 and GATA4 in sequence as the hypoblast becomes committed.
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