Evidence map›Paper›PMID 37102308›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2023

Retinotopic degeneration of the retina and optic tracts in autosomal dominant Alzheimer's disease.

Suman Adhikari, Yuchuan Qiao, Maxwell Singer, Abhay Sagare, Xuejuan Jiang, Yonggang Shi, John M Ringman, Amir H Kashani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Suman AdhikariWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Yuchuan QiaoMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Maxwell SingerDepartment of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Abhay SagareZilkha Neurogenetics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Xuejuan JiangDepartment of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Yonggang ShiMark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
John M RingmanDepartment of Neurology, Alzheimer's Disease Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Amir H KashaniWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0001-9767-7920

Funding

USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Imaging Cerebral and Retinal Microvasculature in Cerebral Small Vessel DiseaseUH3NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2018 to 2020
$4.3M
Motor, Visual, and Olfactory Changes in Genetic Subtypes of Alzheimer’s DiseaseR01AG062007 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RINGMAN, JOHN M · 2019 to 2023
$4.1M
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationU01NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2023 to 2025
$3.9M
The structural and functional connectome across Alzheimer's disease subtypesU01AG051218 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RINGMAN, JOHN M · 2015 to 2018
$3.6M
Validation of Imaging and Blood-based Small Vessel VCID Biomarkers in Multiethnic PopulationUF1NS100614 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KASHANI, AMIR H, RINGMAN, JOHN M · 2021 to 2021
$2.6M
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG062007NIA NIH HHS U01 AG051218NIH HHS R01AG062007NIH HHS U01AG051218NIH HHS UH3NS100614NINDS NIH HHS U01 NS100614NINDS NIH HHS UF1 NS100614NINDS NIH HHS UH3 NS100614
6 · The paper itself

Abstract

introductionWe investigated the correlation between retinal thickness and optic tract integrity in subjects with autosomal dominant Alzheimer's disease (ADAD) causing mutations.

methodsRetinal thicknesses and diffusion tensor images (DTI) were obtained using optical coherence tomography and magnetic resonance imaging, respectively. The association between retinal thickness and DTI measures was adjusted for age, sex, retinotopy, and correlation between eyes.

resultsOptic tract mean diffusivity and axial diffusivity were negatively correlated with retinotopically defined ganglion cell inner plexiform thickness (GCIPL). Fractional anisotropy was negatively correlated with retinotopically defined retinal nerve fiber layer thickness. There was no correlation between outer nuclear layer (ONL) thickness and any DTI measure. DISCUSSION: In ADAD, GCIPL thickness is significantly associated with retinotopic optic tract DTI measures even in minimally symptomatic subjects. Similar associations were not present with ONL thickness or when ignoring retinotopy. We provide in vivo evidence for optic tract changes resulting from ganglion cell pathology in ADAD.

Indexed as

Alzheimer DiseaseOptic TractHumansMagnetic Resonance ImagingRetinaRetinal Ganglion Cellsautosomal dominant Alzheimer's diseasediffusion tensor imagingganglion cell layerinner plexiform layerLatinooptical coherence tomographyouter nuclear layerretinal thickness

Identifiers

PMID37102308
PMCPMC10603214

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.