Evidence map›Paper›PMID 37102250›Full record

ArticleCancer medicine2023

Prediagnostic markers of insulin resistance and prostate cancer risk and death: A pooled study.

Sylvia H J Jochems, Josef Fritz, Christel Häggström, Pär Stattin, Tanja Stocks

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Sylvia H J JochemsDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0001-7676-1488
Josef FritzDepartment of Translational Medicine, Lund University, Malmö, Sweden.
Christel HäggströmNorthern Registry Centre, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.ORCID 0000-0001-6808-4405
Pär StattinDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Tanja StocksDepartment of Clinical Sciences Lund, Lund University, Lund, Sweden.ORCID 0000-0002-0904-0557
Uppsala University · SEInnsbruck Medical University · ATLund University · SEUmeå University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInsulin resistance has been shown to be related to a higher risk of several cancers, but the association with prostate cancer (PCa) has been inconsistent.

methodsWe investigated prediagnostic markers of insulin resistance in men in four cohorts in Sweden, in relation to PCa risk (total, non-aggressive and aggressive) and PCa death using multivariable-adjusted Cox regression. The number of men, PCa cases and PCa deaths was up to 66,668, 3940 and 473 for plasma glucose and the triglyceride-glucose (TyG) index, and up to 3898, 586 and 102 for plasma insulin, glycated haemoglobin (HbA1c) and leptin.

resultsHigher HbA1c was related to a lower risk of non-aggressive PCa but no significant associations were found for insulin resistance markers with the risk of aggressive or total PCa. In PCa cases, higher glucose and TyG index were related to a higher risk of PCa death (hazard ratio [HR] per higher standard deviation, 1.22, 95% CI 1.00-1.49 and 1.24, 95% CI 1.00-1.55), which further increased when restricting the analyses to glucose and TyG index measures taken <10 years before the PCa diagnosis (HR, 1.70, 95% CI 1.09-2.70 and 1.66, 95% CI 1.12-2.51). No associations were observed for other markers in relation to PCa death.

conclusionsThe results of this study showed no associations of insulin resistance markers with the risk of clinically relevant PCa, but higher glucose and TyG index were associated with poorer survival from PCa. The lack of association for other insulin resistance markers may be due to their smaller sample size.

Indexed as

Insulin ResistanceProstatic NeoplasmsBiomarkersBlood GlucoseGlucoseGlycated HemoglobinHumansMaleRisk FactorsTriglyceridesBiomarkersBlood GlucoseGlucoseGlycated HemoglobinTriglyceridesinsulin resistanceprospective studiesprostatic neoplasms

Identifiers

PMID37102250
PMCPMC10315749
OpenAlexW4367174299

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.