Evidence map›Paper›PMID 37102157›Full record

ArticleContact (Thousand Oaks (Ventura County, Calif.))

Autophagy of the ER requires actin assembly driven by the interaction of ER with endocytic pits.

Peter Novick, Dongmei Liu, Susan Ferro-Novick

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contact (Thousand Oaks (Ventura County, Calif.)). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Peter NovickDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0668.
Dongmei LiuDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0668.
Susan Ferro-NovickDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093-0668.
University of California San Diego · US

Funding

GENETICS OF SECRETION IN YEASTR01GM035370 · NIGMS · YALE UNIVERSITY · PI PETER Jay NOVICK · 1985 to 2026
$7.0M
The diverse roles of ER-Golgi trafficking machinery in autophagy and ER quality controlR35GM131681 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Susan FERRO-NOVICK · 2019 to 2026
$5.5M
Genetics of Secretion in YeastR37GM035370 · NIGMS · YALE UNIVERSITY · PI NOVICK, PETER JAY · 2001 to 2010
$3.9M
NIGMS NIH HHS R01 GM035370NIGMS NIH HHS R35 GM131681NIGMS NIH HHS R37 GM035370
6 · The paper itself

Abstract

Autophagy of the cortical ER in budding yeast was unexpectedly found to require End3, a component of the endocytic machinery that promotes the assembly of actin at endocytic pits on the plasma membrane. The cortical ER transiently interacts with invaginating endocytic pits through a linkage consisting of VAP proteins, oxysterol binding proteins and type I myosins. These proteins are required for actin assembly and for autophagy of the ER. Assembly of actin at these contact sites may direct the movement of ER away from the cortex towards sites of autophagosome assembly.

Indexed as

actin assemblyautophagyautophagy receptorendocytosisendoplasmic reticulumVAP

Identifiers

PMID37102157
PMCPMC10129067
OpenAlexW4226284495

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.