ArticleAddiction neuroscience2023
Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress.
Article in Addiction neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers.Journal of psychopharmacology (Oxford, England) · 2024Trial
- Combined maternal separation and limited bedding-nesting increase goal tracking, delay discounting, and impulsive action, and moderate sign-tracking-perseverance associations in male rats.BMC neuroscience · 2026Article
- Maternal deprivation and adolescent alcohol exposure induce sex-dependent alterations in stress-related behavior and lipid signaling in rats.Biology of sex differences · 2026Article
- The oxytocin system mediates behavioral and neurobiological alterations associated with early adversity.Molecular psychiatry · 2026Article
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.Translational psychiatry · 2026Article
- Early life adversity increases striatal dopamine D1 receptor density and promotes social alcohol drinking in mice, especially males.bioRxiv : the preprint server for biology · 2025Article
- Characterization of inflammatory and neurofunctional markers in the context of early life stress among a clinical sample of people maintained on buprenorphine for opioid use disorder.Brain, behavior, & immunity - health · 2025Article
- Interactive effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and behavior.Neurobiology of stress · 2025Article
- Early life stress modulates behavioral sensitivity to alcohol and promotes escalation of alcohol drinking.bioRxiv : the preprint server for biology · 2025Article
- Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood.Neurobiology of learning and memory · 2025Article
- Sex- and reward-dependent effects of early life scarcity-adversity on adolescent behavioral responses to natural rewards.Frontiers in behavioral neuroscience · 2025Article
- Influence of Diet on Reproducible Corticosterone Levels in a Mouse Model of Maternal Separation with Early Weaning.Life (Basel, Switzerland) · 2024Article
- Neuroscience in addiction research.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Effects of Maternal Separation on Effort-based Responding for Sucrose Are Associated with c-Fos Expression in the Nucleus Accumbens Core.Neuroscience · 2024Article
- Early social isolation differentially affects the glucocorticoid receptor system and alcohol-seeking behavior in male and female Marchigian Sardinian alcohol-preferring rats.Neurobiology of stress · 2024Article
- Sexually dimorphic effects of a modified adolescent social isolation paradigm on behavioral risk factors of alcohol use disorder in Long Evans Rats.Addiction neuroscience · 2023Article
- Early-life stress and ovarian hormones alter transcriptional regulation in the nucleus accumbens resulting in sex-specific responses to cocaine.Cell reports · 2023Article
Corrections and comments
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Abstract
In humans, exposure to early life stress (ELS) is an established risk factor for the development of substance use disorders (SUDs) during later life. Similarly, rodents exposed to ELS involving disrupted mother-infant interactions, such as maternal separation (MS) or adverse caregiving due to scarcity-adversity induced by limited bedding and nesting (LBN) conditions, also exhibit long-term alterations in alcohol and drug consumption. In both humans and rodents, there is a range of addiction-related behaviors that are associated with drug use and even predictive of subsequent SUDs. In rodents, these include increased anxiety-like behavior, impulsivity, and novelty-seeking, altered alcohol and drug intake patterns, as well as disrupted reward-related processes involving consummatory and social behaviors. Importantly, the expression of these behaviors often varies throughout the lifespan. Moreover, preclinical studies suggest that sex differences play a role in how exposure to ELS impacts reward and addiction-related phenotypes as well as underlying brain reward circuitry. Here, addiction-relevant behavioral outcomes and mesolimbic dopamine (DA) dysfunction resulting from ELS in the form of MS and LBN are discussed with a focus on age- and sex-dependent effects. Overall, these findings suggest that ELS may increase susceptibility for later life drug use and SUDs by interfering with the normal maturation of reward-related brain and behavioral function.
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