Evidence map›Paper›PMID 37101365›Full record

ArticlePediatric blood & cancer2023

Maternal migraine and risk of pediatric cancers.

Helen T Orimoloye, Julia E Heck, Andrew Charles, Chai Saechao, Di He, Noah Federman, Jorn Olsen, Beate Ritz, Johnni Hansen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric blood & cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Temporal clustering of neuroblastic tumours in children and young adults from Scotland.Environmental health : a global access science source · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Helen T OrimoloyeCollege of Health and Public Service, University of North Texas, Denton, Texas, USA.ORCID 0000-0002-3895-3363
Julia E HeckCollege of Health and Public Service, University of North Texas, Denton, Texas, USA.ORCID 0000-0001-8713-8413
Andrew CharlesGoldberg Migraine Program, Department of Neurology, UCLA Geffen School of Medicine, Los Angeles, California, USA.
Chai SaechaoUCLA Health, University of California, Los Angeles, California, USA.
Di HeDepartment of Epidemiology, Fielding School of Public Health, Los Angeles, California, USA.ORCID 0000-0002-3589-4484
Noah FedermanDepartment of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID 0000-0002-2627-6772
Jorn OlsenDepartment of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
Beate RitzDepartment of Epidemiology, Fielding School of Public Health, Los Angeles, California, USA.
Johnni HansenDanish Cancer Society Research Center, Copenhagen, Denmark.ORCID 0000-0002-9342-2725
University of California, Los Angeles · USFielding Graduate University · USUniversity of North Texas · USAarhus University · DKDanish Cancer Society · DK

Funding

Maternal comorbidities, prescription drug use in pregnancy and childhood cancerR21CA175959 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HECK, JULIA · 2014 to 2015
$323k
NCI NIH HHS R21 CA175959
6 · The paper itself

Abstract

backgroundMaternal migraine has been linked to adverse birth outcomes including low birth weight and preterm birth, as well as congenital anomalies in offspring. It has been speculated that this may be due to the use of medications in pregnancy, but lifestyle, genetic, hormonal, and neurochemical factors could also play a role. There is evidence for varying cancer incidences among adults with migraine. Here, we utilized data from national registries in Denmark to examine associations between maternal diagnoses of migraine and risk for cancer in offspring.

methodsWe linked several national registries in Denmark to identify cases from the Cancer Registry among children less than 20 years (diagnoses 1996-2016) and controls from the Central Population Register, matched to cases by birth year and sex (25:1 matching rate). Migraine diagnoses were identified from the National Patient Register using International Classification of Diseases, versions 8 and 10 codes and migraine-specific acute or prophylactic treatment recorded in the National Pharmaceutical Register. We used logistic regression to estimate the risk of childhood cancers associated with maternal migraine.

resultsMaternal migraine was positively associated with risk for non-Hodgkin lymphoma (odds ratio [OR] = 1.70, 95% confidence interval [CI]: 1.01-2.86), central nervous system tumors ([OR = 1.31, 95% CI: 1.02-1.68], particularly glioma [OR = 1.64, 95% CI: 1.12-2.40]), neuroblastoma (OR = 1.75, 95% CI: 1.00-3.08), and osteosarcoma (OR = 2.60, 95% CI: 1.18-5.76).

conclusionsAssociations with maternal migraine were observed for several childhood cancers, including neuronal tumors. Our findings raise questions about the role of lifestyle factors, sex hormones, genetic, and neurochemical factors in the relationship between migraine and childhood cancers.

Indexed as

Central Nervous System NeoplasmsLymphoma, Non-HodgkinMigraine DisordersPregnancy ComplicationsPremature BirthAdultChildFemaleHumansInfant, NewbornPregnancyRegistriesRisk Factorscentral nervous system tumorschildhood cancerestrogengerm cell tumorsmigrainenon-Hodgkin lymphomaosteosarcomapregnancy

Identifiers

PMID37101365
PMCPMC10278537
OpenAlexW4367174657

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.