ArticleActa neuropathologica communications2023
Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Acta neuropathologica communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 5 pooled it
8.6field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- GWAS meta-analysis of cerebrospinal fluid Alzheimer's biomarkers reveals loci regulating lipids, brain volume and autophagy.Nature communications · 2026Pooled it
- Genome-wide association analyses identify candidate loci for amyloid imaging and plasma biomarkers in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition.Nature communications · 2025Pooled it
- Linking genomic and proteomic signatures to brain amyloid burden: insights from GR@ACE/DEGESCO.Functional & integrative genomics · 2025Pooled it
- Harmonization of CSF and imaging biomarkers in Alzheimer's disease: Need and practical applications for genetics studies and preclinical classification.Neurobiology of disease · 2024Pooled it
- A new era of genome-wide association studies in the field of Alzheimer's disease and overlapping co-pathologies: lessons learned from a neuropathology-centered approach.Acta neuropathologica · 2026Review
- Advances in Alzheimer's disease: mechanistic insights and therapeutic targets.Science China. Life sciences · 2026Review
- Translating genome-wide association studies at multiple scales: Drug target prioritization, cellular architectures, and organ imaging.Cell genomics · 2026Review
- Article
- Contributions of the Alzheimer's Disease Neuroimaging Initiative to advancing AD research: a targeted review of recent publications.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- CMV titer associations with cognition and the plasma proteome implicate FLT1 and neurovascular mechanisms as potential moderators.Journal of neuroinflammation · 2026Article
- Genetic analysis of neurodegenerative diseases.The Journal of clinical investigation · 2026Review
- RNA-seq variants reveal distinct patterns in the aging epitranscriptome: an in-depth analysis of age-matched Alzheimer's Disease patients and a cognitively normal cohort.bioRxiv : the preprint server for biology · 2026Article
- Common and rare variant analyses implicateNPJ dementia · 2026Article
- Association of APOC1 with cortical atrophy during conversion to Alzheimer's disease.GeroScience · 2025Article
- High-sensitivity plasma proteomics reveals disease-specific signatures and predictive biomarkers of Alzheimer's disease phenotypes in a large mixed-dementia cohort.Molecular neurodegeneration · 2025Article
- Apolipoprotein E and Alzheimer's disease pathology in a diverse autopsy study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Mendelian Randomization Reveals Unidirectional Links Between Amyloid-β and Tau in Alzheimer's Disease.Dementia and neurocognitive disorders · 2025Article
- The Genetics of Amyloid Deposition: A Systematic Review of Genome-Wide Association Studies Using Amyloid PET Imaging in Alzheimer's Disease.Journal of imaging · 2025Review
- Combating Genetic Heterogeneity for Polygenic Prediction of Susceptibility to Brain β-Amyloid Deposition: BeyondNeurology. Genetics · 2025Article
Corrections and comments
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Authors and funding
55 authors at 19 institutions in 4 countries.
Muhammad Ali *Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Derek B Archer *Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Priyanka GorijalaDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Daniel WesternDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Jigyasha TimsinaDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Maria V FernándezDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Ting-Chen WangVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Claudia L SatizabalGlenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, UT Health, San Antonio, TX, 78229, USA.
Qiong YangDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Alexa S BeiserDepartment of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Ruiqi WangBoston University, Boston, MA, USA.
Gengsheng ChenKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Brian GordonKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Tammie L S BenzingerKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Chengjie XiongKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
John C MorrisKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Randall J BatemanKnight Alzheimer's Disease Research Center, Washington University, St Louis, MO, USA.
Celeste M KarchDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Eric McDadeDepartment of Neurology, Washington University, St Louis, MO, USA.
Alison GoateDepartment of Neuroscience, Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.
Richard P MayeuxThe Department of Neurology, Columbia University, New York, NY, USA.
Reisa A SperlingDepartment of Neurology, Harvard Medical School, Boston, MA, USA.
Rachel F BuckleyBrigham and Women's Hospital and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Keith A JohnsonMassachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hong-Hee WonDepartment of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Sang-Hyuk JungDepartment of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Hang-Rai KimDepartment of Neurology, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Republic of Korea.
Sang Won SeoDepartment of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Hee Jin KimDepartment of Digital Health, Samsung Medical Center, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea.
Elizabeth MorminoDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Simon M LawsCentre for Precision Health, Edith Cowan University, 270 Joondalup Dr, Joondalup, WA, 6027, Australia.
Kang-Hsien FanDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
M Ilyas KambohDepartment of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA.
Prashanthi VemuriDepartment of Radiology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA.
Vijay K RamananDepartment of Neurology, Mayo Clinic-Minnesota, Rochester, MN, 55905, USA.
Hyun-Sik YangDepartment of Neurology, Brigham and Women's Hospital, Boston, MA, USA.
Allen WenzelWisconsin Alzheimer's Institute, Madison, WI, USA.
Hema Sekhar Reddy RajulaUMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Aniket MishraUMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Carole DufouilUMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Stephanie DebetteUMR 1219, University of Bordeaux, INSERM, Bordeaux Population Health Research Centre, Team ELEANOR, 33000, Bordeaux, France.
Oscar L LopezDepartment of Neurology, University of Pittsburgh, Pittsburgh, PA, USA.
Steven T DeKoskyDepartment of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Feifei TaoNeurogenomics, Genetics-Guided Dementia Discovery, Eisai, Inc, Cambridge, MA, USA.
Michael W NagleNeurogenomics, Genetics-Guided Dementia Discovery, Eisai, Inc, Cambridge, MA, USA.
Knight Alzheimer Disease Research Center (Knight ADRC)
Dominantly Inherited Alzheimer Network (DIAN)
Alzheimer’s Disease Neuroimaging Initiative (ADNI)
ADNI-DOD, A4 Study Team
Australian Imaging Biomarkers, Lifestyle (AIBL) Study
Timothy J HohmanVanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Yun Ju SungDepartment of Psychiatry, Washington University, St. Louis, MO, 63110, USA.
Logan Dumitrescu *Vanderbilt Memory and Alzheimer's Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Carlos Cruchaga *Department of Psychiatry, Washington University, St. Louis, MO, 63110, USA. cruchagac@wustl.edu.ORCID 0000-0002-0276-2899
Washington University in St. Louis · USVanderbilt University · USSamsung Medical Center · KRBoston University · USMallinckrodt (United States) · USUniversité de Bordeaux · FRUniversity of Pittsburgh · USBrigham and Women's Hospital · USEisai (United States) · USMayo Clinic · USAlzheimer's Association · USBroad Institute · USColumbia University · USEdith Cowan University · AUHarvard University · USIcahn School of Medicine at Mount Sinai · USPrevent Alzheimer’s Disease 2020 · USStanford University · USUniversity of Florida · US
Funding
The Alzheimer's Clinical Trial Consortium - Down Syndrome Network (ACTC- DSN)U24AG057437 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Paul S. Aisen, RONALD C PETERSEN · 2018 to 2026
$198.4MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MSmartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Suzanne Elizabeth Schindler · 1985 to 2026
$69.5MVascular Moderators of the Impact of Alzheimer's Pathology in the Young-OldP01AG025204 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOWARD J AIZENSTEIN, Ann D. Cohen · 2005 to 2026
$56.5MImaging CoreU19AG032438 · NIA · WASHINGTON UNIVERSITY · PI BATEMAN, RANDALL J · 2010 to 2025
$53.9MSUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MTHE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9MGINKGO BILOBA PREVENTION TRIAL IN OLDER INDIVIDUALSU01AT000162 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOPEZ, OSCAR L. · 1999 to 2009
$34.7MResearch Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Carolyn Wei Zhu · 2020 to 2026
$31.0MNCCIH NIH HHS U01 AT000162NIA NIH HHS K01 AG073584NIA NIH HHS K23 AG062750NIA NIH HHS L30 AG060964NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG025204NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066468NIA NIH HHS P30 AG066514NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG034676NIA NIH HHS R01 AG041851NIA NIH HHS R01 AG044546NIA NIH HHS R01 AG056366NIA NIH HHS R01 AG063689NIA NIH HHS R01 AG064877NIA NIH HHS R01 AG073439NIA NIH HHS R37 AG011378NIA NIH HHS RF1 AG053303NIA NIH HHS RF1 AG058501NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG058922NIA NIH HHS U19 AG032438NIA NIH HHS U24 AG021886NIA NIH HHS U24 AG057437NIH HHS S10 OD025214
Abstract
Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in the brain and to study Alzheimer's disease (AD). We performed a genome-wide association study on the largest collection of amyloid imaging data (N = 13,409) to date, across multiple ethnicities from multicenter cohorts to identify variants associated with brain amyloidosis and AD risk. We found a strong APOE signal on chr19q.13.32 (top SNP: APOE ɛ4; rs429358; β = 0.35, SE = 0.01, P = 6.2 × 10
Indexed as
Alzheimer DiseaseAmyloidosisAmyloidAmyloid beta-PeptidesApolipoproteins EFemaleGenome-Wide Association StudyHumansAmyloidAmyloid beta-PeptidesApolipoproteins EAlzheimer’s diseaseAmyloid PETBrain amyloidosisGWASMeta-analysisMulti-ethnic
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