Evidence map›Paper›PMID 37101218›Full record

ArticleGenome biology2023

MORC proteins regulate transcription factor binding by mediating chromatin compaction in active chromatin regions.

Zhenhui Zhong, Yan Xue, C Jake Harris, Ming Wang, Zheng Li, Yunqing Ke, Mukun Liu, Jessica Zhou, Yasaman Jami-Alahmadi, Suhua Feng and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
14.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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  14. bioRxiv : the preprint server for biology · 2024
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  16. Review
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  19. Article
  20. The MOM1 complex recruits the RdDM machinery via MORC6 to establishbioRxiv : the preprint server for biology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Zhenhui Zhong *Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Yan Xue *Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
C Jake HarrisDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Ming WangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Zheng LiDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Yunqing KeDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Mukun LiuDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Jessica ZhouDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
Yasaman Jami-AlahmadiDepartment of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA.
Suhua FengDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA.
James A WohlschlegelDepartment of Biological Chemistry, University of California, Los Angeles, CA, 90095, USA.
Steven E JacobsenDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095, USA. jacobsen@ucla.edu.
University of California, Los Angeles · USHoward Hughes Medical Institute · USUniversity of Cambridge · GB

Funding

Epigenetic gene regulation in ArabidopsisR35GM130272 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JACOBSEN, STEVEN E · 2019 to 2023
$1.6M
6 · The paper itself

Abstract

backgroundThe microrchidia (MORC) proteins are a family of evolutionarily conserved GHKL-type ATPases involved in chromatin compaction and gene silencing. Arabidopsis MORC proteins act in the RNA-directed DNA methylation (RdDM) pathway, where they act as molecular tethers to ensure the efficient establishment of RdDM and de novo gene silencing. However, MORC proteins also have RdDM-independent functions although their underlying mechanisms are unknown.

resultsIn this study, we examine MORC binding regions where RdDM does not occur in order to shed light on the RdDM-independent functions of MORC proteins. We find that MORC proteins compact chromatin and reduce DNA accessibility to transcription factors, thereby repressing gene expression. We also find that MORC-mediated repression of gene expression is particularly important under conditions of stress. MORC-regulated transcription factors can in some cases regulate their own transcription, resulting in feedback loops.

conclusionsOur findings provide insights into the molecular mechanisms of MORC-mediated chromatin compaction and transcription regulation.

Indexed as

ArabidopsisArabidopsis ProteinsChromatinDNA MethylationGene Expression Regulation, PlantGene SilencingTranscription FactorsArabidopsis ProteinsChromatinTranscription FactorsChromatin compactionMicrorchidiaMORCTF bindingTranscription regulation

Identifiers

PMID37101218
PMCPMC10131428
OpenAlexW4367052524

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.