ArticleGenes & nutrition2023
25(OH)Vitamin D and autism spectrum disorder: genetic overlap and causality.
Article in Genes & nutrition, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Vitamin D supplementation in the first 2 years and autism spectrum traits at 6-8 years - a randomized clinical trial.Journal of child psychology and psychiatry, and allied disciplines · 2026Trial
- Effects of nutritional supplementation on social impairment and behavioral dysregulation in autism spectrum disorder: a network meta-analysis.BMC psychiatry · 2026Article
- Causal effects of single-carbon metabolism and vitamin levels on autism spectrum disorder risk: a bidirectional Mendelian randomized study.Italian journal of pediatrics · 2026Article
- Fat-soluble vitamin deficiency in children with neurodevelopmental disorders: a cross-sectional study.BMC medicine · 2026Article
- Shared Genetic Links Between Birth Weight and Developmental-Behavioral Disorders.Genes, brain, and behavior · 2025Article
- Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4-Mediated PI3K/AKT Signaling in an Autism Mouse Model.CNS neuroscience & therapeutics · 2025Article
- Related differences in fecal bacteria of Chinese northern pregnant women of different ages: associations with maternal clinical indicators and neonatal outcomes.Frontiers in microbiology · 2025Article
- [Advances in Mendelian randomization studies on autism spectrum disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Review
- Association between 25(OH) vitamin D and schizophrenia: shared genetic correlation, pleiotropy, and causality.Frontiers in nutrition · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo identify whether there exists a genetic correlation and causal relationship between 25(OH)D and autism spectrum disorder (ASD).
methodsBased on large-scale genome-wide association studies, a series of genetic approaches were adopted to obtain summary statistics. Using linkage disequilibrium score regression, we assessed the shared polygenic structure between traits and performed pleiotropic analysis under composite null hypothesis (PLACO) to identify pleiotropic loci between complex traits. A bidirectional Mendelian randomization (MR) analysis was applied to investigate whether there is a causal relationship between 25(OH)D and ASD.
resultsThe linkage disequilibrium score regression (LDSC) showed a negative genetic correlation between 25(OH)D and ASD (r
conclusionThis study provides evidence for a shared genetic overlap between 25(OH)D and ASD. Bidirectional MR analysis also did not show a definite causal relationship between 25(OH)D and ASD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.