ArticleLa Radiologia medica2023
Unambiguous radiologic extranodal extension determined by MRI could be a biomarker in predicting metastatic prostate cancer.
Article in La Radiologia medica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 4 citations in OpenAlex.
- MRI-detected extranodal extension as a marker of prostate cancer aggressiveness.European radiology · 2025Article
- Reply to the Letter to the Editor: MRI-detected extranodal extension as a marker of prostate cancer aggressiveness.European radiology · 2025Article
- Letter to the Editor: MRI-detected extranodal extension as a marker of prostate cancer aggressiveness.European radiology · 2025Article
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7 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo explore the relationship between unambiguous radiologic extranodal extension (rENE) and M1 staging in patients with metastatic PCa.
methodsA respective analysis of 1073 patients of PCa N1 staging from January 2004 to May 2022 was retrospectively enrolled. They were divided into rENE + and rENE - groups and retrospectively analyzed the M staging with nuclear medicine data. The correlation index between unambiguous rENE and M1b staging was calculated. Logistic regression was used to evaluate the predictive performance of unambiguous rENE in M1b staging. ROC curves were used to investigate the relationship between unambiguous rENE and M staging in patients who underwent
resultsA total of 1073 patients were included. Seven hundred and eighty patients were classified into the rENE + group (mean age, 69.6 years ± 8.7 [standard deviation]), and 293 were classified into rENE - group (mean age, 66.7 years ± 9.4 [standard deviation]). Relationship between unambiguous rENE and M1b existed (r = 0.58, 95%CI: 0.52-0.64, P < 0.05). Unambiguous rENE could be an independent predictor for M1b (OR = 13.64, 95%CI: 9.23-20.14, P < 0.05). The AUC of unambiguous rENE in predicting M1b and M staging was 0.835 and 0.915, respectively, in patients who underwent
conclusionsUnambiguous rENE could be a strong biomarker to predict M1b and M staging in patients with PCa. When rENE came up, patients should perform nuclear medicine immediately, and a systematic treatment should be considered.
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