Evidence map›Paper›PMID 37100994›Full record

ArticleNature metabolism2023

Total daily energy expenditure has declined over the past three decades due to declining basal expenditure, not reduced activity expenditure.

John R Speakman, Jasper M A de Jong, Srishti Sinha, Klaas R Westerterp, Yosuke Yamada, Hiroyuki Sagayama, Philip N Ainslie, Liam J Anderson, Lenore Arab, Kweku Bedu-Addo and 70 more

Open access · greenAbstract readLetter
In one paragraph

Article in Nature metabolism, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 63 citations in OpenAlex.

  1. Energy constraint on human health.Trends in endocrinology and metabolism: TEM · 2026
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  17. Energy expenditure and obesity across the economic spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

80 authors at 20 institutions in 22 countries.

John R Speakman *Shenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China. j.speakman@abdn.ac.uk.ORCID http://orcid.org/0000-0002-2457-1823
Jasper M A de Jong *Department of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Srishti Sinha *St Johns Medical college, Bengaluru, India.ORCID http://orcid.org/0000-0001-7000-1816
Klaas R Westerterp *School of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands. k.westerterp@maastrichtuniversity.nl.ORCID http://orcid.org/0000-0003-0842-6850
Yosuke YamadaNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan. yyamada831@gmail.com.ORCID http://orcid.org/0000-0002-4284-6317
Hiroyuki SagayamaFaculty of Health and Sport Sciences, University of Tsukuba, Ibaraki, Japan. sagayama.hiroyuki.ka@u.tsukuba.ac.jp.
Philip N AinslieResearch Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Liam J AndersonSchool of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.ORCID http://orcid.org/0000-0003-3130-355X
Lenore ArabDavid Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Kweku Bedu-AddoDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Stephane BlancNutritional Sciences, University of Wisconsin, Madison, WI, USA.
Alberto G BonomiPhillips Research, Eindhoven, the Netherlands.
Pascal BovetUniversity Center for Primary care and Public Health (Unisanté), Lausanne University Hospital, Lausanne, Switzerland.
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, UK.
Maciej S BuchowskiDivision of Gastroenterology, Hepatology and Nutritiion, Department of Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0002-0566-1743
Nancy F ButteDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Stefan G J A CampsSchool of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0003-2053-1135
Jamie A CooperNutritional Sciences, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8265-4360
Richard CooperDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.
Sai Krupa DasJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0788-0461
Peter S W DaviesChild Health Research Centre, Centre for Children's Health Research, University of Queensland, South Brisbane, Queensland, Australia.
Lara R DugasDepartment of Public Health Sciences, Parkinson School of Health Sciences and Public Health, Loyola University, Maywood, IL, USA.ORCID http://orcid.org/0000-0002-0692-8585
Ulf EkelundDepartment of Sport Medicine, Norwegian School of Sport Sciences, Oslo, Norway.ORCID http://orcid.org/0000-0003-2115-9267
Sonja EntringerCharité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Institute of Medical Psychology, Berlin, Germany.
Terrence ForresterSolutions for Developing Countries, University of the West Indies, Kingston, Jamaica.ORCID http://orcid.org/0000-0001-7976-8669
Barry W FudgeUniversity of Glasgow, Glasgow, UK.
Melanie GillinghamDepartment of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, USA.
Santu GhoshSt Johns Medical college, Bengaluru, India.ORCID http://orcid.org/0000-0002-9373-9570
Annelies H GorisIMEC within OnePlanet Research Center, Wageningen, the Netherlands.ORCID http://orcid.org/0000-0002-4115-5186
Michael GurvenDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.ORCID http://orcid.org/0000-0002-5661-527X
Lewis G HalseySchool of Life and Health Sciences, University of Roehampton, London, UK.ORCID http://orcid.org/0000-0002-0786-7585
Catherine HamblyInstitute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.ORCID http://orcid.org/0000-0002-2947-4539
Hinke H HaismaPopulation Research Centre, Faculty of Spatial Sciences, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-9676-0463
Daniel HoffmanDepartment of Nutritional Sciences, Program in International Nutrition, Rutgers University, New Brunswick, NJ, USA.
Sumei HuShenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0002-3618-4492
Annemiek M JoosenSchool of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands.
Jennifer L KaplanDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA.
Peter KatzmarzykPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-9280-6022
William E KrausDepartment of Medicine, Duke University, Durham, NC, USA.ORCID http://orcid.org/0000-0003-1930-9684
Robert F KushnerNorthwestern University, Chicago, IL, USA.
William R LeonardDepartment of Anthropology, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-6233-604X
Marie LöfDepartment of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2273-4430
Corby K MartinPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-8125-4015
Eric MatsikoDepartment of Human Nutrition and Dietetics, University of Rwanda, Kigali, Rwanda.ORCID http://orcid.org/0000-0002-4374-7441
Anine C MedinDepartment of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Kristiansand, Norway.ORCID http://orcid.org/0000-0003-4154-6264
Erwin P MeijerSchool of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0002-3510-004X
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Center and School of Public Health, University of Washington, Seattle, WA, USA.
Theresa A NicklasDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA.
Robert M OjiamboMoi University, Eldoret, Kenya.
Kirsi H PietiläinenHelsinki University Central Hospital, Helsinki, Finland.ORCID http://orcid.org/0000-0002-8522-1288
Jacob Plange-RhuleDepartment of Physiology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Guy PlasquiDepartment of Nutrition and Movement Sciences, Maastricht University, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0003-4629-6479
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Center and School of Public Health, University of Washington, Seattle, WA, USA.
Susan B RacetteProgram in Physical Therapy and Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6932-1887
David A RaichlenBiological Sciences and Anthropology, University of Southern California, Los Angeles, CA, USA.
Eric RavussinPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0003-2129-547X
Leanne M RedmanPennington Biomedical Research Center, Baton Rouge, LA, USA.ORCID http://orcid.org/0000-0002-7267-7374
Susan B RobertsJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1320-8460
Michael C RudolphDepartment of Physiology and Harold Hamm Diabetes Center, Oklahoma University Health Sciences, Oklahoma City, OK, USA.ORCID http://orcid.org/0000-0002-6147-212X
Luis B SardinhaExercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisboa, Portugal.
Albertine J SchuitUniversity of Tilburg, Tilburg, the Netherlands.
Analiza M SilvaExercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-8984-8600
Eric SticeStanford University, Stanford, CA, USA.
Samuel S UrlacherDepartment of Anthropology, Baylor University, Waco, TX, USA.
Giulio ValentiSchool of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands.
Ludo M Van EttenSchool of Nutrition and Translational Research in Metabolism (NUTRIM), University of Maastricht, Maastricht, the Netherlands.ORCID http://orcid.org/0000-0003-2914-2056
Edgar A Van MilMaastricht University, Campus Venlo and Lifestyle Medicine Center for Children, Jeroen Bosch Hospital's-Hertogenbosch, Hertogenbosch, the Netherlands.
Brian M WoodUniversity of California Los Angeles, Los Angeles, CA, USA.
Jack A YanovskiSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8542-1637
Tsukasa YoshidaNational Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan.ORCID http://orcid.org/0000-0003-2304-6872
Xueying ZhangShenzhen Key Laboratory of Metabolic Health, Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.ORCID http://orcid.org/0000-0001-5746-2191
Alexia J Murphy-AlfordNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.ORCID http://orcid.org/0000-0001-7095-3796
Cornelia U LoechlNutritional and Health Related Environmental Studies Section, Division of Human Health, International Atomic Energy Agency, Vienna, Austria.ORCID http://orcid.org/0000-0001-7959-6270
Anura KurpadSt Johns Medical college, Bengaluru, India. a.kurpad@sjri.res.in.ORCID http://orcid.org/0000-0001-7998-2438
Amy H LukeDivision of Epidemiology, Department of Public Health Sciences, Loyola University School of Medicine, Maywood, IL, USA. aluke@luc.edu.ORCID http://orcid.org/0000-0001-8484-9439
Herman PontzerEvolutionary Anthropology, Duke University, Durham, NC, USA. pontzer@gmail.com.ORCID http://orcid.org/0000-0003-2397-6543
Matthew S RodehefferDepartment of Comparative Medicine, Yale School of Medicine, New Haven, CT, USA. matthew.rodeheffer@gmail.com.ORCID http://orcid.org/0000-0001-8893-2125
Jennifer RoodPennington Biomedical Research Center, Baton Rouge, LA, USA. jennifer.rood@pbrc.edu.ORCID http://orcid.org/0000-0001-5848-2987
Dale A SchoellerBiotech Center and Nutritional Sciences, University of Wisconsin, Madison, WI, USA. dschoell@nutrisci.wisc.edu.ORCID http://orcid.org/0000-0002-5770-3853
William W WongDepartment of Pediatrics, Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center, Houston, TX, USA. wwong@bcm.edu.ORCID http://orcid.org/0000-0002-7147-5850
Maastricht University · NLPennington Biomedical Research Center · USChildren's Nutrition Research Center at Baylor College of Medicine · USInternational Atomic Energy Agency · ATDuke University · USKwame Nkrumah University of Science and Technology · GHLoyola University Chicago · USNorthwestern University · USSt.John's Medical College Hospital · INTufts University · USUniversity of Aberdeen · GBUniversity of California, Los Angeles · USUniversity of Lisbon · PTUniversity of Washington · USYale University · USBaylor University · USBeijing Technology and Business University · CNCentre National de la Recherche Scientifique · FRCentre universitaire de médecine générale et santé publique, Lausanne · CHHelsinki University Hospital · FI

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Washington University Nutrition Obesity Research CenterP30DK056341 · NIDDK · WASHINGTON UNIVERSITY · PI Dominic N Reeds · 1999 to 2026
$30.2M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Nutrition and Physical Activity Assessment Study (NPAAS)R01CA119171 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Marian L Neuhouser · 2006 to 2026
$14.3M
Cellular & molecular mechanisms of white adipose tissue mass regulationR01DK090489 · NIDDK · YALE UNIVERSITY · PI RODEHEFFER, MATTHEW S · 2011 to 2020
$3.8M
The role of mitochondrial dynamics in diet-influenced regulation of food intake and adiposityR01DK126447 · NIDDK · YALE UNIVERSITY · PI HORVATH, TAMAS L, RODEHEFFER, MATTHEW S · 2021 to 2024
$2.3M
Early Life Fatty Acid Exposures Dictate Obesity PredispositionK01DK109079 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RUDOLPH, MICHAEL C. · 2017 to 2021
$686k
Early Life n-3 Fatty Acids Increase Novel Adipogenesis-Regulatory Cells to Condition Adipogenesis in a NR2F2 Dependent MannerR03DK122189 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RUDOLPH, MICHAEL C. · 2019 to 2020
$225k
Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000641Medical Research Council MC_UU_00006/4NCATS NIH HHS UL1 TR002369NCI NIH HHS R01 CA119171NIDDK NIH HHS K01 DK109079NIDDK NIH HHS P30 DK056341NIDDK NIH HHS P30 DK072476NIDDK NIH HHS R01 DK090489NIDDK NIH HHS R01 DK126447NIDDK NIH HHS R03 DK122189Wellcome Trust
6 · The paper itself

Abstract

Obesity is caused by a prolonged positive energy balance

Indexed as

ExerciseHealth ExpendituresBasal MetabolismEnergy MetabolismFemaleHumansMaleObesityUnited States

Identifiers

PMID37100994
PMCPMC10445668
OpenAlexW4367048865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.