Evidence map›Paper›PMID 37100971›Full record

ArticleMolecular neurobiology2023

Suppression of Microglial ERO1a Alleviates Inflammation and Enhances the Efficacy of Rehabilitative Training After Ischemic Stroke.

Jing Ren, Yuan Lv, Qiuyan Tian, Li Sun, Po Miao, Xiaofeng Yang, Li-Xiao Xu, Chen-Xi Feng, Mei Li, Qin Gu and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Jing Ren *Soochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China.
Yuan Lv *Department of Neonatology, Northern Jiangsu People's Hospital, Yangzhou, 225000, China.
Qiuyan TianPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, 215025, China.
Li SunSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China.
Po MiaoSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China.
Xiaofeng YangSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China.
Li-Xiao XuPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, 215025, China.
Chen-Xi FengPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, 215025, China.
Mei LiPediatrics Research Institute, Children's Hospital of Soochow University, Suzhou, 215025, China.
Qin GuDepartment of Rehabilitation, Children's Hospital of Soochow University, Suzhou, 215025, China.
Xing FengSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China. xing_feng66@suda.edu.cn.
Xin DingSoochow Key Laboratory of Prevention and Treatment of Child Brain Injury, Children's Hospital of Soochow University, No.92 Zhongnanjie Road, Suzhou, 215025, Jiangsu, China. dingxin@suda.edu.cn.ORCID http://orcid.org/0000-0002-0387-3240
Soochow University · CNNorthern Jiangsu People's Hospital · CN

Funding

National Natural Science Foundation of China 82271739
6 · The paper itself

Abstract

Microglia mediated inflammation plays a crucial role in cellular events and functional recovery post ischemic stroke. In the current study, we profiled the proteome changes of microglia treated with oxygen and glucose deprivation (OGD). Bioinformatics analysis identified that differentially expressed proteins (DEPs) were enriched in pathways associated with oxidate phosphorylation and mitochondrial respiratory chain at both 6h and 24h post OGD. We next focused on one validated target named endoplasmic reticulum oxidoreductase 1 alpha (ERO1a) to study its role in stroke pathophysiology. We showed that over-expression of microglial ERO1a exacerbated inflammation, cell apoptosis and behavioral outcomes post middle cerebral artery occlusion (MCAO). In contrast, suppression of microglial ERO1a significantly reduced activation of both microglia and astrocyte, along with cell apoptosis. Furthermore, knocking down microglial ERO1a improved the efficacy of rehabilitative training and enhanced the mTOR activity in spared corticospinal neurons. Our study provided novel insights into the identification of therapeutic targets and the design of rehabilitative protocols to treat ischemic stroke and other traumatic CNS injuries.

Indexed as

Brain IschemiaIschemic StrokeStrokeHumansInfarction, Middle Cerebral ArteryInflammationMicrogliaCorticospinal neuronsERO1aFunctional recoveryIschemic strokeMicrogliamTORRehabilitative training

Identifiers

PMID37100971
OpenAlexW4367174608

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.