Evidence map›Paper›PMID 37100955›Full record

ReviewCell death and differentiation2023

Apoptotic cell death in disease-Current understanding of the NCCD 2023.

Ilio Vitale, Federico Pietrocola, Emma Guilbaud, Stuart A Aaronson, John M Abrams, Dieter Adam, Massimiliano Agostini, Patrizia Agostinis, Emad S Alnemri, Lucia Altucci and 218 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell death and differentiation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 249 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
249citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

249 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Programmed cell death in human respiratory syncytial virus infection.Frontiers in cellular and infection microbiology · 2025
    Pooled it
  3. Pooled it
  4. Review
  5. Article
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  7. Review
  8. Review
  9. Itaconate metabolism in regulated cell death.Molecular and cellular biochemistry · 2026
    Review
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  11. Review
  12. Review
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  14. Review
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  16. Review
  17. Review
  18. Article
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  20. Article

189 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

228 authors.

Ilio VitaleIIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy. iliovit@gmail.com.ORCID 0000-0002-5918-1841
Federico PietrocolaDepartment of Biosciences and Nutrition, Karolinska Institute, Huddinge, Sweden.
Emma GuilbaudDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Stuart A AaronsonDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
John M AbramsDepartment of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Dieter AdamInstitut für Immunologie, Kiel University, Kiel, Germany.
Massimiliano AgostiniDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Patrizia AgostinisDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Emad S AlnemriDepartment of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA, USA.
Lucia AltucciDepartment of Precision Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Ivano AmelioDivision of Systems Toxicology, Department of Biology, University of Konstanz, Konstanz, Germany.
David W AndrewsSunnybrook Research Institute, Toronto, ON, Canada.
Rami I AqeilanHebrew University of Jerusalem, Lautenberg Center for Immunology & Cancer Research, Institute for Medical Research Israel-Canada (IMRIC), Faculty of Medicine, Jerusalem, Israel.
Eli AramaDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Eric H BaehreckeDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Siddharth BalachandranBlood Cell Development and Function Program, Fox Chase Cancer Center, Philadelphia, PA, USA.
Daniele BanoDeutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Nickolai A BarlevDepartment of Biomedicine, Nazarbayev University School of Medicine, Astana, Kazakhstan.
Jiri BartekDepartment of Medical Biochemistry and Biophysics, Science for Life Laboratory, Karolinska Institute, Stockholm, Sweden.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Christoph BeckerDepartment of Medicine 1, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
Francesca BernassolaDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Mathieu J M BertrandVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Marco E BianchiUniversità Vita-Salute San Raffaele, School of Medicine, Milan, Italy and Ospedale San Raffaele IRCSS, Milan, Italy.
Mikhail V BlagosklonnyRoswell Park Comprehensive Cancer Center, Buffalo, NY, USA.
J Magarian BlanderDepartment of Medicine, Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, New York, NY, USA.
Giovanni BlandinoIRCSS Regina Elena National Cancer Institute, Rome, Italy.
Klas BlomgrenDepartment of Women's and Children's Health, Karolinska Institute, Stockholm, Sweden.
Christoph BornerInstitute of Molecular Medicine and Cell Research, Medical Faculty, Albert Ludwigs University of Freiburg, Freiburg, Germany.
Carl D BortnerSignal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA.
Pierluigi BoveDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Patricia BoyaCentro de Investigaciones Biologicas Margarita Salas, CSIC, Madrid, Spain.
Catherine BrennerUniversité Paris-Saclay, CNRS, Institut Gustave Roussy, Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques, Villejuif, France.
Petr BrozDepartment of Immunobiology, University of Lausanne, Epalinges, Vaud, Switzerland.
Thomas BrunnerDepartment of Biology, University of Konstanz, Konstanz, Germany.
Rune Busk DamgaardDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
George A CalinDepartment of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Michelangelo CampanellaDepartment of Comparative Biomedical Sciences, The Royal Veterinary College, University of London, London, UK.
Eleonora CandiDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Michele CarboneThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Didac Carmona-GutierrezInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Francesco CecconiCell Stress and Survival Unit, Center for Autophagy, Recycling and Disease (CARD), Danish Cancer Society Research Center, Copenhagen, Denmark.
Francis K-M ChanDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Guo-Qiang ChenState Key Lab of Oncogene and its related gene, Ren-Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Quan ChenCollege of Life Sciences, Nankai University, Tianjin, China.
Youhai H ChenShenzhen Institute of Advanced Technology (SIAT), Shenzhen, Guangdong, China.
Emily H ChengHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jerry E ChipukDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John A CidlowskiSignal Transduction Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, Durham, NC, USA.
Aaron CiechanoverThe Technion-Integrated Cancer Center, The Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Gennaro CilibertoIRCSS Regina Elena National Cancer Institute, Rome, Italy.
Marcus ConradHelmholtz Munich, Institute of Metabolism and Cell Death, Neuherberg, Germany.
Juan R Cubillos-RuizDepartment of Obstetrics and Gynecology, Weill Cornell Medical College, New York, NY, USA.
Peter E CzabotarThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Vincenzo D'AngiolellaDepartment of Oncology, University of Oxford, Oxford, UK.
Mads DaugaardDepartment of Urologic Sciences, Vancouver Prostate Centre, Vancouver, BC, Canada.
Ted M DawsonInstitute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Valina L DawsonInstitute for Cell Engineering and the Departments of Neurology, Neuroscience and Pharmacology & Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ruggero De MariaFondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Bart De StrooperVIB Centre for Brain & Disease Research, Leuven, Belgium.
Klaus-Michael DebatinDepartment of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.
Ralph J DeberardinisHoward Hughes Medical Institute and Children's Medical Center Research Institute, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alexei DegterevDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, MA, USA.
Giannino Del SalDepartment of Life Sciences, University of Trieste, Trieste, Italy.
Mohanish DeshmukhDepartment of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, USA.
Francesco Di VirgilioDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Marc DiederichCollege of Pharmacy, Seoul National University, Seoul, South Korea.
Scott J DixonDepartment of Biology, Stanford University, Stanford, CA, USA.
Brian D DynlachtDepartment of Pathology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA.
Wafik S El-DeiryDivision of Hematology/Oncology, Brown University and the Lifespan Cancer Institute, Providence, RI, USA.
John W ElrodCardiovascular Research Center, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.
Kurt EngelandMolecular Oncology, University of Leipzig, Leipzig, Germany.
Gian Maria FimiaDepartment of Epidemiology, Preclinical Research and Advanced Diagnostics, National Institute for Infectious Diseases 'L. Spallanzani' IRCCS, Rome, Italy.
Claudia GalassiDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Carlo GaniniDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Ana J Garcia-SaezCECAD, Institute of Genetics, University of Cologne, Cologne, Germany.
Abhishek D GargDepartment of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.
Carmen GarridoINSERM, UMR, 1231, Dijon, France.
Evripidis GavathiotisDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Motti GerlicDepartment of Clinical Microbiology and Immunology, Sackler school of Medicine, Tel Aviv university, Tel Aviv, Israel.
Sourav GhoshDepartment of Neurology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.
Douglas R GreenDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Lloyd A GreeneDepartment of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Hinrich GronemeyerDepartment of Functional Genomics and Cancer, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France.
Georg HäckerFaculty of Medicine, Institute of Medical Microbiology and Hygiene, Medical Center, University of Freiburg, Freiburg, Germany.
György HajnóczkyMitoCare Center, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA.
J Marie HardwickDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ygal HauptVITTAIL Ltd, Melbourne, VIC, Australia.
Sudan HeInstitute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
David M HeerySchool of Pharmacy, University of Nottingham, Nottingham, UK.
Michael O HengartnerETH Board, Zurich, Switzerland.
Claudio HetzBiomedical Neuroscience Institute, Faculty of Medicine, University of Chile, Santiago, Chile.
David A HildemanDivision of Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Hidenori IchijoLaboratory of Cell Signaling, The University of Tokyo, Tokyo, Japan.
Satoshi InoueNational Cancer Center Research Institute, Tokyo, Japan.
Marja JäätteläCell Death and Metabolism, Center for Autophagy, Recycling and Disease, Danish Cancer Society Research Center, Copenhagen, Denmark.
Ana JanicDepartment of Medicine and Life Sciences, Pompeu Fabra University, Barcelona, Spain.
Bertrand JosephInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Philipp J JostClinical Division of Oncology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Thirumala-Devi KannegantiDepartment of Immunology, St Jude Children's Research Hospital, Memphis, TN, USA.
Michael KarinDepartments of Pharmacology and Pathology, School of Medicine, University of California San Diego, San Diego, CA, USA.
Hamid KashkarCECAD Research Center, Institute for Molecular Immunology, University of Cologne, Cologne, Germany.
Thomas KaufmannInstitute of Pharmacology, University of Bern, Bern, Switzerland.
Gemma L KellyThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Oliver KeppMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.
Adi KimchiDepartment of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
Richard N KitsisDepartment of Biochemistry, Albert Einstein College of Medicine, New York, NY, USA.
Daniel J KlionskyLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Ruth KluckThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Dmitri V KryskoCell Death Investigation and Therapy Lab, Department of Human Structure and Repair, Ghent University, Ghent, Belgium.
Dagmar KulmsDepartment of Dermatology, Experimental Dermatology, TU-Dresden, Dresden, Germany.
Sharad KumarCentre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
Sergio LavanderoUniversidad de Chile, Facultad Ciencias Quimicas y Farmaceuticas & Facultad Medicina, Advanced Center for Chronic Diseases (ACCDiS), Santiago, Chile.
Inna N LavrikTranslational Inflammation Research, Medical Faculty, Otto von Guericke University, Magdeburg, Germany.
John J LemastersDepartments of Drug Discovery & Biomedical Sciences and Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Gianmaria LiccardiCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
Andreas LinkermannDivision of Nephrology, Department of Internal Medicine 3, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Stuart A LiptonNeurodegeneration New Medicines Center and Department of Molecular Medicine, The Scripps Research Institute, La Jolla, CA, USA.
Richard A LockshinDepartment of Biology, Queens College of the City University of New York, Flushing, NY, USA.
Carlos López-OtínDepartamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain.
Tom LueddeDepartment of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Duesseldorf, Heinrich Heine University, Duesseldorf, Germany.
Marion MacFarlaneMedical Research Council Toxicology Unit, University of Cambridge, Cambridge, UK.
Frank MadeoInstitute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Walter MalorniCenter for Global Health, Università Cattolica del Sacro Cuore, Rome, Italy.
Gwenola ManicIIGM - Italian Institute for Genomic Medicine, c/o IRCSS Candiolo, Torino, Italy.
Roberto MantovaniDipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy.
Saverio MarchiDepartment of Clinical and Molecular Sciences, Marche Polytechnic University, Ancona, Italy.
Jean-Christophe MarineVIB Center for Cancer Biology, Leuven, Belgium.
Seamus J MartinDepartment of Genetics, Trinity College, Dublin, 2, Ireland.
Jean-Claude MartinouDepartment of Cell Biology, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
Pier G MastroberardinoDepartment of Molecular Genetics, Rotterdam, the Netherlands.
Jan Paul MedemaLaboratory for Experimental Oncology and Radiobiology, Center for Experimental and Molecular Medicine, Cancer Center Amsterdam, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Patrick MehlenApoptosis, Cancer, and Development Laboratory, Equipe labellisée 'La Ligue', LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, Lyon, France.
Pascal MeierThe Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, London, UK.
Gerry MelinoDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Sonia MelinoDepartment of Chemical Science and Technologies, University of Rome Tor Vergata, Rome, Italy.
Edward A MiaoDepartment of Immunology, Duke University School of Medicine, Durham, NC, USA.
Ute M MollDepartment of Pathology and Stony Brook Cancer Center, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
Cristina Muñoz-PinedoInstitut d'Investigació Biomèdica de Bellvitge (IDIBELL), L'Hospitalet de Llobregat, Spain.
Daniel J MurphySchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Maria Victoria Niklison-ChirouDepartment of Pharmacy & Pharmacology, Centre for Therapeutic Innovation, University of Bath, Bath, UK.
Flavia NovelliThoracic Oncology, University of Hawaii Cancer Center, Honolulu, HI, USA.
Gabriel NúñezDepartment of Pathology and Rogel Cancer Center, The University of Michigan, Ann Arbor, MI, USA.
Andrew OberstDepartment of Immunology, University of Washington, Seattle, WA, USA.
Dimitry OfengeimRare and Neuroscience Therapeutic Area, Sanofi, Cambridge, MA, USA.
Joseph T OpfermanDepartment of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, USA.
Moshe OrenDepartment of Molecular Cell Biology, The Weizmann Institute, Rehovot, Israel.
Michele PaganoDepartment of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine and Howard Hughes Medical Institute, New York, NY, USA.
Theocharis PanaretakisInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Manolis PasparakisCECAD, Institute of Genetics, University of Cologne, Cologne, Germany.
Josef M PenningerIMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
Francesca PentimalliDepartment of Medicine and Surgery, LUM University, Casamassima, Bari, Italy.
David M PereiraREQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
Shazib PervaizDepartment of Physiology, YLL School of Medicine, National University of Singapore, Singapore, Singapore.
Marcus E PeterDepartment of Medicine, Division Hematology/Oncology, Northwestern University, Chicago, IL, USA.
Paolo PintonDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Giovanni PortaCenter of Genomic Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy.
Jochen H M PrehnDepartment of Physiology and Medical Physics, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin 2, Ireland.
Hamsa PuthalakathDepartment of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC, Australia.
Gabriel A RabinovichLaboratorio de Glicomedicina. Instituto de Biología y Medicina Experimental (IBYME), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
Krishnaraj RajalingamCell Biology Unit, University Medical Center Mainz, Mainz, Germany.
Kodi S RavichandranVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Markus RehmInstitute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany.
Jean-Ehrland RicciUniversité Côte d'Azur, INSERM, C3M, Equipe labellisée Ligue Contre le Cancer, Nice, France.
Rosario RizzutoDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Nirmal RobinsonCentre for Cancer Biology, University of South Australia, Adelaide, SA, Australia.
Cecilia M P RodriguesResearch Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Lisbon, Portugal.
Barak RotblatDepartment of Life sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
Carla V RothlinDepartment of Immunobiology and Department of Pharmacology, Yale School of Medicine, New Haven, CT, USA.
David C RubinszteinDepartment of Medical Genetics, Cambridge Institute for Medical Research, Cambridge, UK.
Thomas RudelMicrobiology Biocentre, University of Würzburg, Würzburg, Germany.
Alessandro RufiniDipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy.
Kevin M RyanSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Kristopher A SarosiekJohn B. Little Center for Radiation Sciences, Harvard School of Public Health, Boston, MA, USA.
Akira SawaJohns Hopkins Schizophrenia Center, Johns Hopkins University, Baltimore, MD, USA.
Emre SayanFaculty of Medicine, Cancer Sciences Unit, University of Southampton, Southampton, UK.
Kate SchroderInstitute for Molecular Bioscience, The University of Queensland, St Lucia, QLD, Australia.
Luca ScorranoDepartment of Biology, University of Padua, Padua, Italy.
Federico SestiDepartment of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers University, NJ, USA.
Feng ShaoNational Institute of Biological Sciences, Beijing, PR China.
Yufang ShiDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Giuseppe S SicaDepartment of Surgical Science, University Tor Vergata, Rome, Italy.
John SilkeThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Hans-Uwe SimonInstitute of Pharmacology, University of Bern, Bern, Switzerland.
Antonella SistiguDipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy.
Anastasis StephanouEuropean University Cyprus, School of Medicine, Nicosia, Cyprus.
Brent R StockwellDepartment of Biological Sciences and Department of Chemistry, Columbia University, New York, NY, USA.
Flavie StrapazzonIRCCS Fondazione Santa Lucia, Rome, Italy.
Andreas StrasserThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Liming SunState Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, China.
Erwei SunDepartment of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China.
Qiang SunLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Gyorgy SzabadkaiDepartment of Biomedical Sciences, University of Padua, Padua, Italy.
Stephen W G TaitSchool of Cancer Sciences, University of Glasgow, Glasgow, UK.
Daolin TangDepartment of Surgery, The University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.
Nektarios TavernarakisInstitute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece.
Carol M TroyDepartments of Pathology & Cell Biology and Neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA.
Boris TurkDepartment of Biochemistry and Molecular and Structural Biology, J. Stefan Institute, Ljubljana, Slovenia.
Nicoletta UrbanoDepartment of Oncohaematology, University of Rome Tor Vergata, TOR, Rome, Italy.
Peter VandenabeeleVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Tom Vanden BergheVIB-UGent Center for Inflammation Research, Ghent, Belgium.
Matthew G Vander HeidenKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Jacqueline L VanderluitDivision of BioMedical Sciences, Memorial University, St. John's, NL, Canada.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
Andreas VillungerInstitute for Developmental Immunology, Biocenter, Medical University of Innsbruck, Innsbruck, Austria.
Silvia von KarstedtDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
Anne K VossThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Karen H VousdenThe Francis Crick Institute, London, UK.
Domagoj VucicDepartment of Early Discovery Biochemistry, Genentech, South San Francisco, CA, USA.
Daniela VuriDepartment of Experimental Medicine, University of Rome Tor Vergata, TOR, Rome, Italy.
Erwin F WagnerDepartment of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.
Henning WalczakCenter for Biochemistry, Medical Faculty, University of Cologne, Cologne, Germany.
David WallachDepartment of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel.
Ruoning WangCenter for Childhood Cancer and Blood Diseases, Abigail Wexner Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA.
Ying WangShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Achim WeberUniversity of Zurich and University Hospital Zurich, Department of Pathology and Molecular Pathology, Zurich, Switzerland.
Will WoodCentre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.
Takahiro YamazakiDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA.
Huang-Tian YangShanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Zahra ZakeriQueens College and Graduate Center, City University of New York, Flushing, NY, USA.
Joanna E Zawacka-PankauDepartment of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden.
Lin ZhangDepartment of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Haibing ZhangCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai, China.
Boris ZhivotovskyInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Wenzhao ZhouLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.
Mauro PiacentiniDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.ORCID 0000-0003-2919-1296
Guido KroemerMetabolomics and Cell Biology Platforms, Gustave Roussy Cancer Center, Université Paris Saclay, Villejuif, France.ORCID 0000-0002-9334-4405
Lorenzo GalluzziDepartment of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA. deadoc80@gmail.com.ORCID 0000-0003-2257-8500

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Role of Autophagy in T Cell Function and Immunosenescence (Project 3)P01AG031782 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MACIAN, FERNANDO · 2009 to 2024
$36.2M
Leadership in AD/ADRD Drug DiscoveryR35AG071734 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI LIPTON, STUART A · 2021 to 2025
$5.4M
Regulation of autophagy during animal developmentR35GM131689 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Eric H Baehrecke · 2019 to 2026
$4.9M
Small Molecule Activators of Pro-apoptotic BAX for Cancer TherapyR01CA178394 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GAVATHIOTIS, EVRIPIDIS · 2014 to 2024
$3.7M
Metabolic programming in TH17 cell differentiationR01AI114581 · NIAID · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2015 to 2025
$3.6M
S-Nitrosylation-Induced Posttranslational Modification and Aberrant Cell Signaling in Sporadic Alzheimer's DiseaseR01AG056259 · NIA · SCRIPPS RESEARCH INSTITUTE, THE · PI LIPTON, STUART A · 2017 to 2021
$3.3M
Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patientsR37CA248565 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Kristopher Andrew Sarosiek · 2020 to 2026
$2.6M
Chronic Mitochondrial Division and Melanoma: Mechanism, Prognosis, and TherapyR01CA267696 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jerry Edward Chipuk · 2022 to 2026
$2.4M
The Oncogene Activated Mitochondrial Unfolded Protein Response Regulates Senescence BiologyR01CA271346 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Jerry Edward Chipuk · 2023 to 2026
$2.4M
Modulation of asparagine bioavailability and stress response signaling to enhance T cell robustness and maximize immunotherapyR01CA247941 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI WANG, RUONING · 2021 to 2025
$2.4M
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6 · The paper itself

Abstract

Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis in mammalian systems have elucidated the key contribution of this process not only to (post-)embryonic development and adult tissue homeostasis, but also to the etiology of multiple human disorders. Consistent with this notion, while defects in the molecular machinery for apoptotic cell death impair organismal development and promote oncogenesis, the unwarranted activation of apoptosis promotes cell loss and tissue damage in the context of various neurological, cardiovascular, renal, hepatic, infectious, neoplastic and inflammatory conditions. Here, the Nomenclature Committee on Cell Death (NCCD) gathered to critically summarize an abundant pre-clinical literature mechanistically linking the core apoptotic apparatus to organismal homeostasis in the context of disease.

Indexed as

ApoptosisCaspasesAnimalsCarcinogenesisCell DeathHumansMammalsCaspases

Identifiers

PMID37100955
PMCPMC10130819

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