ArticleNature2023
A druggable copper-signalling pathway that drives inflammation.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
156citing papers in PubMed, 1 pooled it
47.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
156 citing papers in PubMed, 1 synthesis or guideline pooled it, 294 citations in OpenAlex.
- Bibliometric analysis of metformin as an immunomodulator (2013-2024).Frontiers in immunology · 2024Pooled it
- Cuproptosis in spinal cord injury: emerging mechanisms and immunological relevance.Annals of medicine · 2026Review
- Glycan-decorated polymeric nanomedicine for the treatment of multidrug-resistant infections.Bioactive materials · 2026Article
- Genes, fuel, and fate in lung cancer.Biochemical Society transactions · 2026Review
- Packing-accelerated consecutive NIR excitation (PACE) enables high energy photocatalysis and antitumor immunity in vivo.Science advances · 2026Article
- Revealing the Anti-Inflammatory Mechanisms of Zingiber officinale Roscoe Through Network Pharmacology and Experimental Validation.Biomedical chromatography : BMC · 2026Article
- Mechanisms underlying propagation of ferroptotic cell death.Nature cell biology · 2026Review
- scRNA-seq and bulk RNA-seq reveal the characteristics of macrophage copper metabolism and establish a risk signature in hepatocellular carcinoma.Translational cancer research · 2026Article
- Copper dependency in leukemia metabolism.Nature cancer · 2026Article
- Copper-based metal-organic frameworks: applications and prospects in cancer diagnosis and therapy.RSC advances · 2026Review
- Ion sequential therapy aligned with pathological changes enhances cardiac function after myocardial infarction.Cell reports. Medicine · 2026Article
- Copper homeostasis and cuproptosis rewire the tumor microenvironment: mechanisms, immune modulation, and therapeutic opportunities.Journal of hematology & oncology · 2026Review
- Pro-Inflammatory Vicious Cycle-Normalizing Biomimetic Nanoparticles to Treat Acute Respiratory Distress Syndrome.Advanced healthcare materials · 2026Article
- Emerging role of copper in the pathophysiology of spinal cord injury.Neural regeneration research · 2026Article
- Plasma exchange and abrogation of monocyte activation in Wilson's disease: Letter to the editor on "Acute-on-chronic liver failure: Terminology, mechanisms and management".Clinical and molecular hepatology · 2026Article
- Copper dysregulation in cardiometabolic disease: copper deficiency versus cuproptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Deciphering the Anti-Tumor Mechanisms of Metformin Through Reprogramming of the Tumor Microenvironment.Cells · 2026Review
- Copper Complexes: Emerging Micro- and Nanosystems for Dermatological Treatment.Pharmaceutics · 2026Review
- Synergistic Sunlight-Activated Photodynamic and Near-Infrared-Induced Mild Photothermal Therapy for Infected Wound Healing Using Functionalized Nano-BiAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- MT2A-Mediated Regulation of Cuproptosis in Human Dental Pulp Cells Modulates Macrophage M1 Polarization in Pulpitis.International dental journal · 2026Article
96 more citing papers are in PubMed but not listed here.
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Authors and funding
34 authors at 6 institutions in 3 countries.
Stéphanie Solier *Equipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
Sebastian Müller *Equipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-3423-5364
Tatiana Cañeque *Equipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
Antoine Versini *Equipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0001-9799-2701
Arnaud MansartParis Saclay University, UVSQ, INSERM, 2I, Montigny-le-Bretonneux, France.
Fabien SindikubwaboEquipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-9381-6302
Leeroy BaronEquipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
Laila EmamParis Saclay University, UVSQ, INSERM, 2I, Montigny-le-Bretonneux, France.
Pierre GestraudCBIO-Centre for Computational Biology, Institut Curie, INSERM, Mines ParisTech, Paris, France.ORCID 0000-0002-3893-9879
G Dan PantoșDepartment of Chemistry, University of Bath, Bath, UK.
Vincent GandonInstitut de Chimie Moléculaire et des Matériaux d'Orsay, CNRS, Paris Saclay University, Orsay, France.ORCID 0000-0003-1108-9410
Christine GailletEquipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
Ting-Di WuInstitut Curie, PSL Research University, Paris, France.
Florent DingliCurieCoreTech Mass Spectrometry Proteomic, Institut Curie, PSL Research University, Paris, France.ORCID 0000-0002-7715-2446
Damarys LoewCurieCoreTech Mass Spectrometry Proteomic, Institut Curie, PSL Research University, Paris, France.ORCID 0000-0002-9111-8842
Sylvain BaulandeICGex Next-Generation Sequencing Platform, Institut Curie, PSL Research University, Paris, France.ORCID 0000-0003-3104-1684
Sylvère DurandMetabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.
Valentin SencioUniversité de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, CIIL, Lille, France.ORCID 0000-0002-6379-4317
Cyril RobilUniversité de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, CIIL, Lille, France.ORCID 0000-0002-3607-244X
François TrotteinUniversité de Lille, CNRS, INSERM, CHU Lille, Institut Pasteur de Lille, CIIL, Lille, France.ORCID 0000-0003-3373-1814
David PéricatInstitut of Pharmacology and Structural Biology, University of Toulouse, CNRS, Toulouse, France.
Emmanuelle NäserInstitut of Pharmacology and Structural Biology, University of Toulouse, CNRS, Toulouse, France.
Céline CougouleInstitut of Pharmacology and Structural Biology, University of Toulouse, CNRS, Toulouse, France.
Etienne MeunierInstitut of Pharmacology and Structural Biology, University of Toulouse, CNRS, Toulouse, France.
Anne-Laure BègueInstitut Curie, INSERM, PSL Research University, Paris, France.
Hélène SalmonInstitut Curie, INSERM, PSL Research University, Paris, France.
Nicolas ManelInstitut Curie, INSERM, PSL Research University, Paris, France.ORCID 0000-0002-1481-4430
Alain PuisieuxEquipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France.
Sarah WatsonDepartment of Medical Oncology, Institut Curie, PSL Research University, Paris, France.ORCID 0000-0003-4534-8783
Mark A DawsonPeter MacCallum Cancer Centre and Sir Peter MacCallum Department of Oncology, Melbourne, Victoria, Australia.ORCID 0000-0002-5464-5029
Nicolas ServantCBIO-Centre for Computational Biology, Institut Curie, INSERM, Mines ParisTech, Paris, France.ORCID 0000-0003-1678-7410
Guido KroemerMetabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France.ORCID 0000-0002-9334-4405
Djillali AnnaneParis Saclay University, UVSQ, INSERM, 2I, Montigny-le-Bretonneux, France.
Raphaël RodriguezEquipe Labellisée Ligue Contre le Cancer, Institut Curie, CNRS, INSERM, PSL Research University, Paris, France. raphael.rodriguez@curie.fr.ORCID 0000-0001-7668-446X
Centre National de la Recherche Scientifique · FRInserm · FRUniversité Paris Sciences et Lettres · FRInstitut Gustave Roussy · FRThe University of Melbourne · AUUniversity of Bath · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation is a complex physiological process triggered in response to harmful stimuli
Indexed as
Cell PlasticityCopperInflammationSignal TransductionAnimalsEpigenesis, GeneticHyaluronan ReceptorsHydrogen PeroxideMacrophage ActivationMacrophagesMetforminMiceMitochondriaNADOxidation-ReductionCd44 protein, mouseCopperHyaluronan ReceptorsHydrogen PeroxideMetforminNAD
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.