ArticleNature2023
Multisensory learning binds neurons into a cross-modal memory engram.
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Article
- The larvalScience advances · 2026Article
- Boosting Artificial Olfaction: Visual Cues-Enhanced Gas Classification by a Bimodal Neuromorphic Device.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Biomimetic ferroelectric-semiconductor transistor enables neuronal multisensory integration.Nature communications · 2026Article
- NeuroPupil: A generalization-first framework for scalable and biologically informative cross-species pupillometry.bioRxiv : the preprint server for biology · 2026Article
- Multisensory coding of audiovisual movies in the human hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Bees flexibly adjust decision strategies to information content in a foraging task.Science advances · 2026Article
- The larvalbioRxiv : the preprint server for biology · 2026Article
- Audiovisual Integration Enhances Customer Perception of Artisanal Bread Sounds.Foods (Basel, Switzerland) · 2025Article
- Extinction of Innate Floral Preferences in the Generalist Solitary Pollinator Eristalis tenax.Journal of chemical ecology · 2025Article
- The critical dimension of memory engrams and an optimal number of senses.Scientific reports · 2025Article
- Classical Conditioning of AdultCold Spring Harbor protocols · 2025Article
- Twists to Classical Conditioning of AdultCold Spring Harbor protocols · 2025Article
- Memories of hand movements are tied to speech through learning.Psychonomic bulletin & review · 2025Article
- Network topological reorganization mechanisms of primary visual cortex under multimodal stimulation.Frontiers in neuroscience · 2025Article
- The Drosophila adult brain: short overview of structure, function, and resources Graphical Review Paper.Current research in insect science · 2025Review
- Multisensory vs. unisensory learning: how they shape effective connectivity networks subserving unimodal and multimodal integration.Frontiers in neuroscience · 2025Article
- Neuronal circuit mechanisms of competitive interaction between action-based and coincidence learning.Science advances · 2024Article
- Natural phasic inhibition of dopamine neurons signals cognitive rigidity.bioRxiv : the preprint server for biology · 2024Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
Corrections and comments
- Retraction · 2026-03-25Error in Analyses · Error in Data · Investigation by Third Party · Results Not Reproducible · Unreliable Data ·
- Retracted
Authors and funding
8 authors.
Funding
Abstract
Associating multiple sensory cues with objects and experience is a fundamental brain process that improves object recognition and memory performance. However, neural mechanisms that bind sensory features during learning and augment memory expression are unknown. Here we demonstrate multisensory appetitive and aversive memory in Drosophila. Combining colours and odours improved memory performance, even when each sensory modality was tested alone. Temporal control of neuronal function revealed visually selective mushroom body Kenyon cells (KCs) to be required for enhancement of both visual and olfactory memory after multisensory training. Voltage imaging in head-fixed flies showed that multisensory learning binds activity between streams of modality-specific KCs so that unimodal sensory input generates a multimodal neuronal response. Binding occurs between regions of the olfactory and visual KC axons, which receive valence-relevant dopaminergic reinforcement, and is propagated downstream. Dopamine locally releases GABAergic inhibition to permit specific microcircuits within KC-spanning serotonergic neurons to function as an excitatory bridge between the previously 'modality-selective' KC streams. Cross-modal binding thereby expands the KCs representing the memory engram for each modality into those representing the other. This broadening of the engram improves memory performance after multisensory learning and permits a single sensory feature to retrieve the memory of the multimodal experience.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.