Evidence map›Paper›PMID 37100869›Full record

Trial reportMolecular psychiatry2023

Treating intrusive memories after trauma in healthcare workers: a Bayesian adaptive randomised trial developing an imagery-competing task intervention.

Varsha Ramineni, Philip Millroth, Lalitha Iyadurai, Thomas Jaki, Jonathan Kingslake, Julie Highfield, Charlotte Summers, Michael B Bonsall, Emily A Holmes

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04992390 (A Randomised Optimisation Study of a Brief Digital Imagery-competing Task Intervention to Support NHS ICU Staff Experiencing Intrusive Memories of Traumatic Events From Working in the COVID-19 Pandemic), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04992390 nacompletednot on this map

A Randomised Optimisation Study of a Brief Digital Imagery-competing Task Intervention to Support NHS ICU Staff Experiencing Intrusive Memories of Traumatic Events From Working in the COVID-19 Pandemic

TypeinterventionalSponsorP1vital Products LimitedRan2021 to 2022Enrolled106ConditionsIntrusive Memories of Traumatic Event(s)ArmsBrief digital imagery-competing task intervention
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Varsha RamineniDepartment of Psychology, Uppsala University, Uppsala, Uppsala County, Sweden.ORCID 0000-0002-0330-3184
Philip MillrothDepartment of Psychology, Uppsala University, Uppsala, Uppsala County, Sweden.
Lalitha IyaduraiP1vital Products Ltd, Wallingford, Oxfordshire, UK.
Thomas JakiMRC Biostatistics Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID 0000-0002-1096-188X
Jonathan KingslakeP1vital Products Ltd, Wallingford, Oxfordshire, UK.ORCID 0000-0003-1741-1802
Julie HighfieldIntensive Care Society, Breams Building, London, UK.
Charlotte SummersDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.ORCID 0000-0002-7269-2873
Michael B BonsallDepartment of Biology, University of Oxford, Oxford, Oxfordshire, UK.ORCID 0000-0003-0250-0423
Emily A HolmesDepartment of Psychology, Uppsala University, Uppsala, Uppsala County, Sweden. emily.holmes@psyk.uu.se.ORCID 0000-0001-7319-3112
Uppsala University · SEUniversity of Cambridge · GBIntensive Care Society · GBUniversity of Oxford · GB

Funding

Medical Research Council MC_UU_00002/14Medical Research Council MR/S035753/1Medical Research Council MR/X005070/1Wellcome Trust
6 · The paper itself

Abstract

Intensive care unit (ICU) staff continue to face recurrent work-related traumatic events throughout the COVID-19 pandemic. Intrusive memories (IMs) of such traumatic events comprise sensory image-based memories. Harnessing research on preventing IMs with a novel behavioural intervention on the day of trauma, here we take critical next steps in developing this approach as a treatment for ICU staff who are already experiencing IMs days, weeks, or months post-trauma. To address the urgent need to develop novel mental health interventions, we used Bayesian statistical approaches to optimise a brief imagery-competing task intervention to reduce the number of IMs. We evaluated a digitised version of the intervention for remote, scalable delivery. We conducted a two-arm, parallel-group, randomised, adaptive Bayesian optimisation trial. Eligible participants worked clinically in a UK NHS ICU during the pandemic, experienced at least one work-related traumatic event, and at least three IMs in the week prior to recruitment. Participants were randomised to receive immediate or delayed (after 4 weeks) access to the intervention. Primary outcome was the number of IMs of trauma during week 4, controlling for baseline week. Analyses were conducted on an intention-to-treat basis as a between-group comparison. Prior to final analysis, sequential Bayesian analyses were conducted (n = 20, 23, 29, 37, 41, 45) to inform early stopping of the trial prior to the planned maximum recruitment (n = 150). Final analysis (n = 75) showed strong evidence for a positive treatment effect (Bayes factor, BF = 1.25 × 10

Indexed as

COVID-19SARS-CoV-2Bayes TheoremHealth PersonnelHumansPandemics

Identifiers

PMID37100869
PMCPMC10131522
OpenAlexW4367055603

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.