Evidence map›Paper›PMID 37100673›Full record

ArticleUltrasound in medicine & biology2023

Ambient Pressure Sensitivity of the Subharmonic Response of Coated Microbubbles: Effects of Acoustic Excitation Parameters.

Roozbeh H Azami, Flemming Forsberg, John R Eisenbrey, Kausik Sarkar

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ultrasound in medicine & biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Roozbeh H AzamiDepartment of Mechanical and Aerospace Engineering, George Washington University, Washington, DC, USA.
Flemming ForsbergDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
John R EisenbreyDepartment of Radiology, Thomas Jefferson University, Philadelphia, PA, USA.
Kausik SarkarDepartment of Mechanical and Aerospace Engineering, George Washington University, Washington, DC, USA. Electronic address: sarkar@gwu.edu.
George Washington University · USThomas Jefferson University · US

Funding

Monodisperse Microbubbles for Noninvasive Pressure EstimationR01EB032333 · NIBIB · THOMAS JEFFERSON UNIVERSITY · PI EISENBREY, JOHN, SARKAR, KAUSIK · 2022 to 2025
$2.4M
NIBIB NIH HHS R01 EB032333
6 · The paper itself

Abstract

objectiveThe sensitivity of the acoustic response of microbubbles, specifically a strong correlation between their subharmonic response and the ambient pressure, has motivated development of a non-invasive subharmonic-aided pressure estimation (SHAPE) method. However, this correlation has previously been found to vary depending on the microbubble type, the acoustic excitation and the hydrostatic pressure range. In this study, the ambient pressure sensitivity of microbubble response was investigated.

methodsThe fundamental, subharmonic, second harmonic and ultraharmonic responses from an in-house lipid-coated microbubble were measured for excitations with peak negative pressures (PNPs) of 50-700 kPa and frequencies of 2, 3 and 4 MHz in the ambient overpressure range 0-25 kPa (0-187 mmHg) in an in vitro setup.

resultsThe subharmonic response typically has three stages-occurrence, growth and saturation-with increasing excitation PNP. We find distinct decreasing and increasing variations of the subharmonic signal with overpressure that are closely related to the threshold of subharmonic generation in a lipid-shelled microbubble. Above the excitation threshold, that is, in the growth-saturation phase, subharmonic signals decreased linearly with slopes as high as -0.56 dB/kPa with ambient pressure increase; below the threshold excitation (at atmospheric pressure), increasing overpressure triggers subharmonic generation, indicating a lowering of subharmonic threshold, and therefore leads to an increase in subharmonic with overpressure, the maximum enhancement being ∼11 dB for 15 kPa overpressure at 2 MHz and 100 kPa PNP.

conclusionThis study indicates the possible development of novel and improved SHAPE methodologies.

Indexed as

Contrast MediaMicrobubblesAcousticsLipidsPressureUltrasonographyContrast MediaLipidsAmbient pressure sensitivityLipid-coated microbubblesSubharmonic-aided pressure estimationUltrasound contrast agents

Identifiers

PMID37100673
PMCPMC10306329
OpenAlexW4366992215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.