ArticleJournal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi2023
Sex differences in the central regulation of colorectal motility in response to noxious stimuli.
Article in Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- Autonomic effects of electroacupuncture in opioid-induced constipation in male rats.Physiological reports · 2025Article
- The Role of the Gut Microbiota in Individuals with Irritable Bowel Syndrome: A Scoping Review.Medicina (Kaunas, Lithuania) · 2024Article
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5 authors at 1 institution in 1 country.
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Abstract
Distinct sex differences in the prevalence and symptoms of abnormal bowel habits in patients with irritable bowel syndrome (IBS) have been reported. We have elucidated the sex differences in the regulation of colorectal motility via the central nervous system. Noxious stimuli in the colorectum of anesthetized male rats enhance colorectal motility by activating monoaminergic neurons in descending pain inhibitory pathways from the brainstem to the lumbosacral spinal cord. These monoaminergic neurons release serotonin and dopamine into the lumbosacral spinal cord, resulting in the increment of colorectal motility. In female rats, in contrast, noxious stimuli in the colorectum have no effect on colorectal motility. We clarified that GABAergic inhibition in the lumbosacral spinal cord masks the enhancement of colorectal motility induced by monoamines in female animals. Considering that IBS patients often show visceral hypersensitivity and hyperalgesia, our studies suggest that differences in the descending neurons that respond to painful stimuli are involved in various sex differences in abnormal bowel habits.
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