Evidence map›Paper›PMID 37100164›Full record

ArticleThe Annals of thoracic surgery2023

Procedure-Specific Center Volume and Mortality After Infantile Congenital Heart Surgery.

Rachel Zmora, Logan Spector, John Bass, Amanda Thomas, Jessica Knight, Kamakshi Lakshminarayan, James St Louis, Lazaros Kochilas

Open access · bronzeAbstract read
In one paragraph

Article in The Annals of thoracic surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Rachel ZmoraSection of Preventive Medicine & Epidemiology, Boston University School of Medicine, Boston, Massachusetts. Electronic address: rachel.zmora@northwestern.edu.
Logan SpectorDepartment of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.
John BassDepartment of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota.
Amanda ThomasDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota.
Jessica KnightDepartment of Epidemiology and Biostatistics, University of Georgia College of Public Health, Athens, Georgia.
Kamakshi LakshminarayanDivision of Epidemiology & Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota.
James St LouisDepartment of Pediatrics, Medical College of Georgia, Augusta, Georgia.
Lazaros KochilasDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia.
University of Minnesota · USAugusta University · USBoston University · USEmory University · USGeorgia College & State University · US

Funding

Long-term Outcomes after Interventions for Congenital Heart DiseaseR01HL122392 · NHLBI · UNIVERSITY OF MINNESOTA · PI KOCHILAS, LAZAROS K. · 2014 to 2022
$5.2M
Multidisciplinary Training Program in Cardiovascular EpidemiologyT32HL125232 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Matthew G. Nayor, Vanessa Xanthakis · 2016 to 2026
$5.0M
Long-term outcomes in patients with single ventricle physiologyR21HL145486 · NHLBI · EMORY UNIVERSITY · PI KOCHILAS, LAZAROS K. · 2019 to 2020
$234k
NHLBI NIH HHS R01 HL122392NHLBI NIH HHS R21 HL145486NHLBI NIH HHS T32 HL125232
6 · The paper itself

Abstract

backgroundRegionalization of congenital heart surgery (CHS) has been proposed to improve postsurgical outcomes by increasing experience in the care of high-risk patients. We sought to determine whether procedure-specific center volume was associated with mortality after infantile CHS up to 3 years post-procedure.

methodsWe analyzed data from 12,263 infants in the Pediatric Cardiac Care Consortium undergoing CHS between 1982 and 2003 at 46 centers within the United States. We used logistic regression to assess the association between procedure-specific center volume and mortality from discharge to 3 years post-procedure, accounting for clustering at the center level and adjusting for patient age and weight at surgery, chromosomal abnormality, and surgical era.

resultsWe found decreased odds for in-hospital mortality for Norwood procedures (odds ratio [OR] 0.955, 95% CI 0.935-0.976), arterial switch operations (OR 0.924, 95% CI 0.889-0.961), tetralogy of Fallot repairs (OR 0.975, 95% CI 0.956-0.995), Glenn shunts (OR 0.971, 95% CI 0.943-1.000), and ventricular septal defect closures (OR 0.974, 95% CI 0.964-0.985). The association persisted up to 3 years post-surgery for Norwood procedures (OR 0.971, 95% CI 0.955-0.988), arterial switches (OR 0.929, 95% CI 0.890-0.970), and ventricular septal defect closures (OR 0.986, 95% CI 0.977-0.995); however, after excluding deaths that occurred within the first 90 days of following surgery, we observed no association between center volume and mortality for any of the procedures studied.

conclusionsThese findings suggest that procedure-specific center volume is inversely associated with early postoperative mortality for infantile CHS across the complexity spectrum but has no measurable effect on later mortality.

Indexed as

Cardiac Surgical ProceduresHeart Defects, CongenitalHeart Septal Defects, VentricularNorwood ProceduresChildHospital MortalityHumansInfantTreatment OutcomeUnited States

Identifiers

PMID37100164
PMCPMC10524585
OpenAlexW4366817882

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.