Evidence map›Paper›PMID 37099932›Full record

ReviewJournal of biomechanics2023

Structure-Function relationships in the skeletal muscle extracellular matrix.

Richard L Lieber, Gretchen Meyer

Abstract readReview
In one paragraph

Review in Journal of biomechanics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Spastic Paresis: A Treatable Movement Disorder.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Richard L LieberShirley Ryan AbilityLab, Departments of Physical Medicine and Rehabilitation, Physiology and Biomedical Engineering, Northwestern University, Chicago, IL, and Hines VA Medical Center, Maywood IL, United States. Electronic address: rlieber@sralab.org.
Gretchen MeyerProgram in Physical Therapy, and Departments of Neurology, Biomedical Engineering and Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, United States.

Funding

National Center for Muscle Rehabilitation ResearchR24HD050837 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L., WARD, SAMUEL RICHARD · 2005 to 2014
$7.2M
Skeletal Muscle Injury: Mechanism Prevention &TreatmentR01AR040050 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIEBER, RICHARD L · 1989 to 2007
$1.6M
Intraoperative Optimization and Validation of Musculoskeletal ReconstructionI01RX002462 · VA · EDWARD HINES JR VA HOSPITAL · PI LIEBER, RICHARD L. · 2018 to 2025
–
RR&D Senior Research Career Scientist Award ApplicationIK6RX003351 · VA · EDWARD HINES JR VA HOSPITAL · PI LIEBER, RICHARD L. · 2020 to 2025
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NIAMS NIH HHS R01 AR040050NICHD NIH HHS R24 HD050837RRD VA I01 RX002462RRD VA IK6 RX003351
6 · The paper itself

Abstract

The vast majority of skeletal muscle biomechanical studies have rightly focused on its active contractile properties. However, skeletal muscle passive biomechanical properties have significant clinical impact in aging and disease and are yet incompletely understood. This review focuses on the passive biomechanical properties of the skeletal muscle extracellular matrix (ECM) and suggests aspects of its structural basis. Structural features of the muscle ECM such as perimysial cables, collagen cross-links and endomysial structures have been described, but the way in which these structures combine to create passive biomechanical properties is not completely known. We highlight the presence and organization of perimysial cables. We also demonstrate that the analytical approaches that define passive biomechanical properties are not necessarily straight forward. For example, multiple equations, such as linear, exponential, and polynomial are commonly used to fit raw stress-strain data. Similarly, multiple definitions of zero strain exist that affect muscle biomechanical property calculations. Finally, the appropriate length range over which to measure the mechanical properties is not clear. Overall, this review summarizes our current state of knowledge in these areas and suggests experimental approaches to measuring the structural and functional properties of skeletal muscle.

Indexed as

Extracellular MatrixMuscle, SkeletalBiomechanical PhenomenaCollagenStructure-Activity RelationshipCollagenComparative biomechanicsMuscle mechanicsPassive stiffnessTitin

Identifiers

PMID37099932
PMCPMC10176458

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.