ArticlePloS one2023
Study investigating executive function in schizophrenia patients and their unaffected siblings.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.
- Cognitive-behavioral therapy for negative symptoms of schizophrenia: A systematic review and meta-analysis.Medicine · 2024Pooled it
- Prefrontal cortex stimulation prevents stress-induced HPA axis reactivity in people at familial risk of schizophrenia.European psychiatry : the journal of the Association of European Psychiatrists · 2025Trial
- Color Perception in Patients with Schizophreniza and Their Healthy First-degree Relatives: A Cross-sectional Study.Indian journal of psychological medicine · 2026Article
- Sex differences in higher-order cognition in schizophrenia and unaffected first-degree relatives: a longitudinal, family study.European archives of psychiatry and clinical neuroscience · 2026Article
- Beyond severity: Mapping cognitive heterogeneity in schizophrenia at the structural level.medRxiv : the preprint server for health sciences · 2026Article
- Valence-Driven Cognitive Flexibility: Neurochemical and Circuit-Level Insights from Animal Models and Their Relevance to Schizophrenia.Biomolecules · 2025Review
- [Relationship between polygenic risk scores for various psychiatric disorders and clinical and neuropsychological characteristics in children with attention-deficit/hyperactivity disorder].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSchizophrenia (SCZ) is characterized by widespread cognitive impairments, such as executive functions. Most of the available research indicate that executive impairment has a certain genetic predisposition. Shared neuropathological characteristics of patients with SCZ and their siblings may reveal intermediate behavioral phenotypes that can be used to further characterize the illness.
methodsOur study involved 32 SCZ patients, 32 unaffected siblings (US), and 33 persons as healthy controls (HCS). These three groups underwent a computerized version of the Wisconsin Card Sorting Test (WCST), and a battery of cognitive neuropsychological assessments. These tests also evaluate executive function and several cognitive domains.
resultsThe performed study on SCZ patients and their unaffected siblings showed an inferior WCST performance to the HCS subjects, further indicating that unaffected siblings have a functional impairment, and they also performed poorly on the neuropsychological assessment compared with the HCS.
conclusionThis result supports the claim that the development of functional impairment is not limited to SCZ patients and unaffected siblings may also have a certain level of abnormal brain function. Consequently. neurological abnormalities lead to the abnormal functioning in siblings and patients, suggesting that genetics plays a considerable role in such results.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.