ArticleNeuro-oncology2023
Social determinants of cognitive outcomes in survivors of pediatric brain tumors treated with conformal radiation therapy.
Article in Neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Child opportunity and cognitive development in a clinically referred sample.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2026Article
- Shared Sociodemographic Risk Factors for Neurocognitive Dysfunction in Children With Cancer and Blood Disorders.Pediatric blood & cancer · 2026Article
- Resources are associated with functional outcome and brain morphometry in childhood cancer survivors.Frontiers in oncology · 2026Article
- Ototoxicity and cognitive outcomes among very young children treated for brain tumors: Findings from a multisite, prospective, longitudinal trial.Neuro-oncology · 2025Article
- Long-term outcome of the Milano-hyperfractionated accelerated radiotherapy strategy for high-risk medulloblastoma, including the impact of molecular subtype.Neuro-oncology · 2025Article
- Academic readiness among young children treated for brain tumors: a multisite, prospective, longitudinal trial.Journal of the National Cancer Institute · 2024Article
- Psychosocial and executive functioning late effects in pediatric brain tumor survivors after proton radiation.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Social determinants of health: A forgotten risk factor for neurocognition in pediatric brain tumor survivors.Neuro-oncology · 2023Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundSocial determinants of health including parental occupation, household income, and neighborhood environment are predictors of cognitive outcomes among healthy and ill children; however, few pediatric oncology studies have investigated this relationship. This study utilized the Economic Hardship Index (EHI) to measure neighborhood-level social and economic conditions to predict cognitive outcomes among children treated for brain tumors (BT) with conformal radiation therapy (RT).
methodsTwo hundred and forty-one children treated on a prospective, longitudinal, phase II trial of conformal photon RT (54-59.4 Gy) for ependymoma, low-grade glioma, or craniopharyngioma (52% female, 79% white, age at RT = 7.76 ± 4.98 years) completed serial cognitive assessments (intelligence quotient [IQ], reading, math, and adaptive functioning) for ten years. Six US census tract-level EHI scores were calculated for an overall EHI score: unemployment, dependency, education, income, crowded housing, and poverty. Established socioeconomic status (SES) measures from the extant literature were also derived.
resultsCorrelations and non-parametric tests revealed EHI variables share modest variance with other SES measures. Income, unemployment, and poverty overlapped most with individual SES measures. Linear mixed models, accounting for sex, age at RT, and tumor location, revealed EHI variables predicted all cognitive variables at baseline and change in IQ and math over time, with EHI overall and poverty most consistent predictors. Higher economic hardship was associated with lower cognitive scores.
conclusionsNeighborhood-level measures of socioeconomic conditions can help inform understanding of long-term cognitive and academic outcomes in survivors of pediatric BT. Future investigation of poverty's driving forces and the impact of economic hardship on children with other catastrophic diseases is needed.
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