Trial reportJournal of medical Internet research2023
An Unguided, Computerized Cognitive Behavioral Therapy Intervention (TreadWill) in a Lower Middle-Income Country: Pragmatic Randomized Controlled Trial.
Trial report in Journal of medical Internet research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03445598 (A Novel and Adaptive Software for Automated Delivery of Cognitive Behavioral Therapy), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Novel and Adaptive Software for Automated Delivery of Cognitive Behavioral Therapy
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials.BMJ health & care informatics · 2026Pooled it
- Long-Term Effectiveness of Unguided Internet-Based Cognitive Behavioral Therapy on Major Depressive Disorder in Chinese Adults: Randomized Controlled Trial With a 12-Month Follow-Up.JMIR mHealth and uHealth · 2026Trial
- A scalable mental health intervention for depressive symptoms: evidence from a randomized controlled trial and large-scale real-world studies.NPJ digital medicine · 2025Article
- Effects of the Soothe Vision well-being tool on university students' mood: a pilot study.Current psychology (New Brunswick, N.J.) · 2025Article
- Mechanisms underlying cognitive impairment and management strategies in type 2 diabetes.Frontiers in endocrinology · 2025Review
- Digital interventions for common mental disorders in low- and middle-income countries: A systematic review and meta-analysis.Global mental health (Cambridge, England) · 2023Review
- Effectiveness and cost-effectiveness of an integrated digital psychological intervention (Digital healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGlobally, most individuals who are susceptible to depression do not receive adequate or timely treatment. Unguided computerized cognitive behavioral therapy (cCBT) has the potential to bridge this treatment gap. However, the real-world effectiveness of unguided cCBT interventions, particularly in low- and middle-income countries (LMICs), remains inconclusive.
objectiveIn this study, we aimed to report the design and development of a new unguided cCBT-based multicomponent intervention, TreadWill, and its pragmatic evaluation. TreadWill was designed to be fully automated, engaging, easy to use, and accessible to LMICs.
methodsTo evaluate the effectiveness of TreadWill and the engagement level, we performed a double-blind, fully remote, and randomized controlled trial with 598 participants in India and analyzed the data using a completer's analysis.
resultsThe users who completed at least half of the modules in TreadWill showed significant reduction in depression-related (P=.04) and anxiety-related (P=.02) symptoms compared with the waitlist control. Compared with a plain-text version with the same therapeutic content, the full-featured version of TreadWill showed significantly higher engagement (P=.01).
conclusionsOur study provides a new resource and evidence for the use of unguided cCBT as a scalable intervention in LMICs.
trial registrationClinicalTrials.gov NCT03445598; https://clinicaltrials.gov/ct2/show/NCT03445598.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.