ArticleWorld journal of pediatrics : WJP2023
Interactions between long interpregnancy interval and advanced maternal age on neonatal outcomes.
Article in World journal of pediatrics : WJP, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- The association between interpregnancy intervals and preterm birth: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Combined hormonal versus nonhormonal versus progestin-only contraceptives for postpartum contraception in lactating individuals.The Cochrane database of systematic reviews · 2026Article
- High-Risk Fertility Behavior and Its Associated Factors Among Women in Wad Madani Maternity Hospital, Sudan: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Pre-pregnancy BMI modifies the optimal interpregnancy interval for preventing preterm birth: a population-based retrospective cohort study.Frontiers in endocrinology · 2026Article
- Maternal sociodemographic characteristics of short and long interpregnancy intervals in Japan: an analysis using national birth data.BMC public health · 2025Article
- Relationship between inter-pregnancy interval and risk of adverse maternal and neonatal outcomes in subsequent twin pregnancies.BMC pregnancy and childbirth · 2025Article
- Maternal Age Differences in Interpregnancy Interval and Preterm Birth Associations Accounting for Multiple Epidemiologic Biases.Paediatric and perinatal epidemiology · 2025Article
- Association between interpregnancy interval and adverse perinatal outcomes according to maternal age in the context of China's two-child policy.BMC pregnancy and childbirth · 2025Article
- Interpregnancy Interval After Healthy Live Birth and Subsequent Spontaneous Abortion.JAMA network open · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAfter the implementation of the universal two-child policy in China, it was more frequent to have long interpregnancy intervals (IPIs) and advanced maternal age. However, the interactions between long IPIs and advanced maternal age on neonatal outcomes are unknown.
methodsThe study subjects of this historical cohort study were multiparas with singleton live births between October 1st, 2015, and October 31st, 2020. IPI was defined as the interval between delivery and conception of the subsequent pregnancy. Logistic regression models were used to calculate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) of the risks of preterm birth (PTB), low birth weight (LBW), small for gestation age, and 1-min Apgar score ≤ 7 in different IPI groups. Relative excess risk due to interaction (RERI) was used to evaluate the additive interaction between long IPIs and advanced maternal age.
resultsCompared with the 24 ≤ IPI ≤ 59 months group, the long IPI group (IPI ≥ 60 months) was associated with a higher risk of PTB (aOR, 1.27; 95% CI: 1.07-1.50), LBW (aOR, 1.32; 95% CI 1.08-1.61), and one-minute Apgar score ≤ 7 (aOR, 1.46; 95% CI 1.07-1.98). Negative additive interactions (all RERIs < 0) existed between long IPIs and advanced maternal age for these neonatal outcomes. Meanwhile, IPI < 12 months was also associated with PTB (aOR, 1.51; 95% CI 1.13-2.01), LBW (aOR, 1.50; 95% CI 1.09-2.07), and 1-min Apgar score ≤ 7 (aOR, 1.93; 95% CI 1.23-3.04).
conclusionsBoth short and long IPIs are associated with an increased risk of adverse neonatal outcomes. Appropriate IPI should be recommended to women planning to become pregnant again. In addition, better antenatal care might be taken to balance the inferiority of advanced maternal age and to improve neonatal outcomes.
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