Evidence map›Paper›PMID 37099206›Full record

ArticleCellular and molecular life sciences : CMLS2023

Atrial natriuretic peptide stimulates autophagy/mitophagy and improves mitochondrial function in chronic heart failure.

Salvatore Raffa, Maurizio Forte, Giovanna Gallo, Danilo Ranieri, Simona Marchitti, Damiano Magrì, Marco Testa, Rosita Stanzione, Franca Bianchi, Maria Cotugno and 5 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Natriuretic Peptides as a Biomarker of Cognitive Decline in Hypertension.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
  4. Mitophagy in cardiovascular diseases: a literature review.Cardiovascular diagnosis and therapy · 2026
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Hypertension and Heart Failure: From Pathophysiology to Treatment.International journal of molecular sciences · 2024
    Review
  14. Review
  15. Review
  16. Research progress of autophagy in heart failure.American journal of translational research · 2024
    Review
  17. Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Salvatore Raffa *Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy. salvatore.raffa@uniroma1.it.ORCID http://orcid.org/0000-0001-9501-7638
Maurizio Forte *IRCCS Neuromed, Pozzilli, Isernia, Italy.ORCID http://orcid.org/0000-0003-0739-0534
Giovanna GalloDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Danilo RanieriDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Simona MarchittiIRCCS Neuromed, Pozzilli, Isernia, Italy.
Damiano MagrìDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Marco TestaCardiology Unit, Azienda Ospedaliero-Universitaria Sant'Andrea, Rome, Italy.
Rosita StanzioneIRCCS Neuromed, Pozzilli, Isernia, Italy.
Franca BianchiIRCCS Neuromed, Pozzilli, Isernia, Italy.
Maria CotugnoIRCCS Neuromed, Pozzilli, Isernia, Italy.
Emiliano FioriDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Vincenzo ViscoDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Sebastiano SciarrettaIRCCS Neuromed, Pozzilli, Isernia, Italy.
Massimo VolpeDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy.
Speranza RubattuDepartment of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University, Rome, Italy. speranzadonatella.rubattu@uniroma1.it.ORCID http://orcid.org/0000-0002-9808-7970
Istituto Neurologico Mediterraneo · ITSapienza University of Rome · ITAzienda Ospedaliera Sant'Andrea · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial dysfunction, causing increased reactive oxygen species (ROS) production, is a molecular feature of heart failure (HF). A defective antioxidant response and mitophagic flux were reported in circulating leucocytes of patients with chronic HF and reduced ejection fraction (HFrEF). Atrial natriuretic peptide (ANP) exerts many cardiac beneficial effects, including the ability to protect cardiomyocytes by promoting autophagy. We tested the impact of ANP on autophagy/mitophagy, altered mitochondrial structure and function and increased oxidative stress in HFrEF patients by both ex vivo and in vivo approaches. The ex vivo study included thirteen HFrEF patients whose peripheral blood mononuclear cells (PBMCs) were isolated and treated with αANP (10

Indexed as

Heart FailureAminobutyratesAngiotensin Receptor AntagonistsAtrial Natriuretic FactorBiphenyl CompoundsHumansLeukocytes, MononuclearMitochondriaMitophagyReactive Oxygen SpeciesStroke VolumeTetrazolesValsartanAminobutyratesAngiotensin Receptor AntagonistsAtrial Natriuretic FactorBiphenyl CompoundsReactive Oxygen SpeciessacubitrilTetrazolesValsartanARNiAutophagosomeCardiac natriuretic peptideCirculating mononuclear cellsLeft ventricular systolic functionMitochondrial membrane potentialMitochondrial oxidative stress

Identifiers

PMID37099206
PMCPMC10133375
OpenAlexW4367047994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.