Evidence map›Paper›PMID 37099126›Full record

ArticleApplied biochemistry and biotechnology2024

DNA Repair Enzyme XRCC4 30 bp Indel Intron 3 Locus Significant Association with Predisposition of Cataract in Senility.

Sanober Kafeel, Neelam Bizenjo, Shams Salman Shivji, Asifa Keran, Zehra Hashim, Syeda Nuzhat Nawab

Abstract read
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In one paragraph

Article in Applied biochemistry and biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sanober KafeelFaculty of Engineering, Science, Technology and Management, Department of Biomedical Engineering, Ziauddin University (ZUFESTM), F-103, Block B, North Nazimabad, Karachi, 74600, Pakistan. sanoberkafeel93@gmail.com.ORCID http://orcid.org/0000-0003-1282-6347
Neelam BizenjoFaculty of Engineering, Science, Technology and Management, Department of Biomedical Engineering, Ziauddin University (ZUFESTM), F-103, Block B, North Nazimabad, Karachi, 74600, Pakistan.
Shams Salman ShivjiFaculty of Engineering, Science, Technology and Management, Department of Biomedical Engineering, Ziauddin University (ZUFESTM), F-103, Block B, North Nazimabad, Karachi, 74600, Pakistan.
Asifa KeranFaculty of Engineering, Science, Technology and Management, Department of Biomedical Engineering, Ziauddin University (ZUFESTM), F-103, Block B, North Nazimabad, Karachi, 74600, Pakistan.
Zehra HashimDr. Zafar H. Zaidi Center for Proteomics (ZCP), University of Karachi, Karachi, 75270, Pakistan.ORCID http://orcid.org/0000-0001-6750-093X
Syeda Nuzhat NawabThe Karachi Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Main University Rd, Karachi, 75270, Pakistan.ORCID http://orcid.org/0000-0002-4828-3287
Ziauddin University · PKUniversity of Karachi · PK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Impaired DNA damage repair cascade can disrupt the lens transparency due to aging-associated oxidative stress. The aim of study was to assess the association of 30 bp indel mutation (rs28360071) in XRCC4 gene with susceptibility of cataract in senility. The study followed case-control design with a total of n = 200 participants and divided equally into senile cataract patients and control groups. Conventional polymerase chain reaction (PCR) was performed for the genotyping of XRCC4 (rs28360071) mutation. In statistical measures, SPSS ® 20.0 software, MedCal©, and SNPStats© tools were used for data analysis. Distribution of homozygous D/D and mutant D allele was higher in senile cataract patients in comparison to controls. XRCC4 (rs28360071) mutation was significantly associated with predisposition senile cataract (χ

Indexed as

CataractPolymorphism, Single NucleotideAgingCase-Control StudiesDNA-Binding ProteinsDNA RepairDNA Repair EnzymesGenetic Predisposition to DiseaseGenotypeHumansINDEL MutationIntronsDNA-Binding ProteinsDNA Repair EnzymesXRCC4 protein, humanAgingDNA damageLens epithelialSenile cataractXRCC4 gene

Identifiers

PMID37099126
OpenAlexW4367047859

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.