Evidence map›Paper›PMID 37098898›Full record

ArticleMicrobiology spectrum2023

Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation.

Erum Razvi, Benjamin R DiFrancesco, Gregory A Wasney, Zachary A Morrison, John Tam, Anick Auger, Perrin Baker, Noor Alnabelseya, Jacquelyn D Rich, Piyanka Sivarajah and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Bacillus cereus PelAThe Journal of biological chemistry · 2026
    Article
  2. AssessingACS infectious diseases · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Exploring the inhibitory potential ofFrontiers in molecular biosciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Erum RazviProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-5555-1438
Benjamin R DiFrancescoDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Gregory A WasneyProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Zachary A MorrisonDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
John TamProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Anick AugerProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Perrin BakerProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Noor AlnabelseyaProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Jacquelyn D RichDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.
Piyanka SivarajahProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Gregory B WhitfieldProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
Joe J HarrisonDepartment of Biological Sciences, University of Calgary, Calgary, Alberta, Canada.ORCID 0000-0003-0368-9539
Roman A MelnykProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-7187-2362
Mark NitzDepartment of Chemistry, University of Toronto, Toronto, Ontario, Canada.
P Lynne HowellProgram in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-2776-062X
University of Toronto · CAHospital for Sick Children · CAUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biosynthesis of the Pel exopolysaccharide in Pseudomonas aeruginosa requires all seven genes of the

Indexed as

Polysaccharides, BacterialPseudomonas aeruginosaBacterial ProteinsBiofilmsEsterasesHumansPeriplasmBacterial ProteinsEsterasesPolysaccharides, Bacterialbiofilmsexopolysaccharidehigh-throughput screeninhibitorsPel polysaccharidePseudomonas aeruginosa

Identifiers

PMID37098898
PMCPMC10269871
OpenAlexW4367047968

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.