Evidence map›Paper›PMID 37098762›Full record

ArticleEuropean journal of immunology2023

Enhanced Mott cell formation linked with IgM Fc receptor (FcμR) deficiency.

Pedram Mahmoudi Aliabadi, Khlowd Al-Qaisi, Peter K Jani, Kazuhito Honjo, Uwe Klemm, Kyeong-Hee Lee, Nicole Baumgarth, Andreas Radbruch, Fritz Melchers, Hiromi Kubagawa

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Pedram Mahmoudi AliabadiHumoral Immune Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
Khlowd Al-QaisiHumoral Immune Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
Peter K JaniLymphocyte Development, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
Kazuhito HonjoDepartment of Medicine, School of Medicine, University of Alabama, Birmingham, USA.
Uwe KlemmExperimental Animals, Max Planck Institute for Infectious Biology, Berlin, Germany.
Kyeong-Hee LeeInflammation Research Group, Institute of Clinical Chemistry, Hannover Medical School, Hanover, Germany.
Nicole BaumgarthDepartment of Molecular Microbiology and immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
Andreas RadbruchDepartment of Cell Biology, Deutsches Rheuma-Forschungszentrum, DRFZ), Berlin, Germany.ORCID 0000-0001-5753-0000
Fritz MelchersLymphocyte Development, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.
Hiromi KubagawaHumoral Immune Regulation, Deutsches Rheuma-Forschungszentrum (DRFZ), Berlin, Germany.ORCID 0000-0001-7195-706X
German Rheumatism Research Centre · DEJohns Hopkins University · USMax Planck Institute for Infection Biology · DEMedizinische Hochschule Hannover · DEUniversity of Alabama at Birmingham · US

Funding

Protective humoral immunity to influenza infectionR01AI117890 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMGARTH, NICOLE · 2016 to 2020
$2.4M
B-1 cells, IgM and Protective Humoral Immunity to InfluenzaR01AI148652 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI BAUMGARTH, NICOLE · 2019 to 2023
$2.4M
NIAID NIH HHS R01 AI117890NIAID NIH HHS R01 AI148652
6 · The paper itself

Abstract

In previous studies, Mott cells, an unusual form of plasma cells containing Ig-inclusion bodies, were frequently observed in peripheral lymphoid tissues in our IgM Fc receptor (FcμR)-deficient (KO) mouse strain. Because of discrepancies in the reported phenotypes of different Fcmr KO mouse strains, we here examined two additional available mutant strains and confirmed that such enhanced Mott-cell formation was a general phenomenon associated with FcμR deficiency. Splenic B cells from Fcmr KO mice clearly generated more Mott cells than those from WT mice when stimulated in vitro with LPS alone or a B-1, but not B-2, activation cocktail. Nucleotide sequence analysis of the Ig variable regions of a single IgMλ

Indexed as

B-LymphocytesReceptors, FcAnimalsImmunoglobulin MMicePlasma CellsImmunoglobulin Mimmunoglobulin M receptorReceptors, FcB-1 B cellsFcμRIg-inclusion bodyMott hybridomaRussel body

Identifiers

PMID37098762
PMCPMC12815582
OpenAlexW4367048016

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.