ArticleKidney research and clinical practice2023
Clinical characteristics of acute kidney injury in patients with glyphosate surfactant herbicide poisoning.
Article in Kidney research and clinical practice, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Evidence-Based Assessment of Pesticide-Related Nephrotoxicity: Clinical Outcomes, Experimental Data, and Molecular Signatures.International journal of molecular sciences · 2026Review
- Association between glyphosate exposure and renal injury: evidence from NHANES 2013-2016.World journal of emergency medicine · 2026Article
- Trehalose prevents glyphosate-induced kidney damage in roosters via inhibiting apoptosis.Veterinary research communications · 2025Article
- The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease.Journal of xenobiotics · 2025Review
- Unusual course of glyphosate-induced acute kidney injury: a case report of tubulointerstitial nephritis treated with steroids.CEN case reports · 2025Article
- A narrative review of contemporary lethal pesticides: unveiling the ongoing threat of pesticide poisoning.Clinical and experimental emergency medicine · 2024Article
- Poisoning-Induced Acute Kidney Injury: A Review.Medicina (Kaunas, Lithuania) · 2024Review
- Anemia and Hypoxia Impact on Chronic Kidney Disease Onset and Progression: Review and Updates.Cureus · 2023Review
- A case of glyphosate poisoning with falsely elevated creatinine levels measured by dry chemistry methods.Acute medicine & surgeryArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundIn this study, we investigated the clinical characteristics of acute kidney injury (AKI) in patients with glyphosate surfactant herbicide (GSH) poisoning.
methodsThis study was performed between 2008 and 2021 and included 184 patients categorized into the AKI (n = 82) and nonAKI (n = 102) groups. The incidence, clinical characteristics, and severity of AKI were compared between the groups based on the Risk of renal dysfunction, Injury to the kidney, Failure or Loss of kidney function, and End-stage kidney disease (RIFLE) classification.
resultsThe incidence of AKI was 44.5%, of which 25.0%, 6.5%, and 13.0% of patients were classified into the Risk, Injury, and Failure categories, respectively. Patients in the AKI group were older (63.3 ± 16.2 years vs. 57.4 ± 17.5 years, p = 0.02) than those in the non-AKI group. The length of hospitalization was longer (10.7 ± 12.1 days vs. 6.5 ± 8.1 days, p = 0.004) and hypotensive episodes occurred more frequently in the AKI group (45.1% vs. 8.8%, p < 0.001). Electrocardiographic (ECG) abnormalities on admission were more frequently observed in the AKI group than in the non-AKI group (80.5% vs. 47.1%, p < 0.001). Patients in the AKI group had poorer renal function (estimated glomerular filtration rate at the time of admission, 62.2 ± 22.9 mL/min/1.73 m2 vs. 88.9 ± 26.1 mL/min/1.73 m2 , p < 0.001) on admission. The mortality rate was higher in the AKI group than in the non-AKI group (18.3% vs. 1.0%, p < 0.001). Multiple logistic regression analysis showed that hypotension and ECG abnormalities upon admission were significant predictors of AKI in patients with GSH poisoning.
conclusionThe presence of hypotension on admission may be a useful predictor of AKI in patients with GSH intoxication.
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