Evidence map›Paper›PMID 37098612›Full record

ArticleAlzheimer's research & therapy2023

Spatial navigation is associated with subcortical alterations and progression risk in subjective cognitive decline.

Qian Chen, Futao Chen, Cong Long, Yajing Zhu, Yaoxian Jiang, Zhengyang Zhu, Jiaming Lu, Xin Zhang, Zuzana Nedelska, Jakub Hort and 1 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's research & therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06561906 recruitingnot on this map

Establish Diagnostic and Prognostic Models for Preclinical AD Patients Based on Multimodal MRI, Behavioral, Genetic, and Plasma Biomarkers

TypeobservationalSponsorThe Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical SchoolRan2020 to 2027Enrolled1,000ConditionsAlzheimer Disease, Late Onset, Mild Cognitive Impairment, Subjective Cognitive DeclineArmsMultimodal magnetic resonance imaging scanning, behavioral, genetic and plasma biomarker testing
NCT07031687 narecruitingnot on this mapstarted 2025, after this paper: background citation

Effects and Mechanisms of Temporal Interference Brain Stimulation on Memory Function in Preclinical Alzheimer's Disease

TypeinterventionalSponsorXuanwu Hospital, BeijingRan2025 to 2029Enrolled1,200ConditionsAlzheimer DiseaseArmsActive TIBS, Sham TIBS
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qian Chen *Department of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Futao Chen *Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Cong Long *Institute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Yajing ZhuDepartment of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, China.
Yaoxian JiangInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Zhengyang ZhuInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Jiaming LuInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Xin ZhangInstitute of Medical Imaging and Artificial Intelligence, Nanjing University, Nanjing, China.
Zuzana NedelskaMemory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czechia.
Jakub HortMemory Clinic, Department of Neurology, 2nd Faculty of Medicine, Charles University, University Hospital Motol, Prague, Czechia.
Bing ZhangDepartment of Radiology, Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, 210008, China. zhangbing_nanjing@nju.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSubjective cognitive decline (SCD) may serve as a symptomatic indicator for preclinical Alzheimer's disease; however, SCD is a heterogeneous entity regarding clinical progression. We aimed to investigate whether spatial navigation could reveal subcortical structural alterations and the risk of progression to objective cognitive impairment in SCD individuals.

methodsOne hundred and eighty participants were enrolled: those with SCD (n = 80), normal controls (NCs, n = 77), and mild cognitive impairment (MCI, n = 23). SCD participants were further divided into the SCD-good (G-SCD, n = 40) group and the SCD-bad (B-SCD, n = 40) group according to their spatial navigation performance. Volumes of subcortical structures were calculated and compared among the four groups, including basal forebrain, thalamus, caudate, putamen, pallidum, hippocampus, amygdala, and accumbens. Topological properties of the subcortical structural covariance network were also calculated. With an interval of 1.5 years ± 12 months of follow-up, the progression rate to MCI was compared between the G-SCD and B-SCD groups.

resultsVolumes of the basal forebrain, the right hippocampus, and their respective subfields differed significantly among the four groups (p < 0.05, false discovery rate corrected). The B-SCD group showed lower volumes in the basal forebrain than the G-SCD group, especially in the Ch4p and Ch4a-i subfields. Furthermore, the structural covariance network of the basal forebrain and right hippocampal subfields showed that the B-SCD group had a larger Lambda than the G-SCD group, which suggested weakened network integration in the B-SCD group. At follow-up, the B-SCD group had a significantly higher conversion rate to MCI than the G-SCD group.

conclusionCompared to SCD participants with good spatial navigation performance, SCD participants with bad performance showed lower volumes in the basal forebrain, a reorganized structural covariance network of subcortical nuclei, and an increased risk of progression to MCI. Our findings indicated that spatial navigation may have great potential to identify SCD subjects at higher risk of clinical progression, which may contribute to making more precise clinical decisions for SCD individuals who seek medical help.

Indexed as

Alzheimer DiseaseCognitive DysfunctionSpatial NavigationDisease ProgressionHumansNeuropsychological TestsBasal forebrainProgression riskSpatial navigationStructural covariance networkSubjective cognitive decline

Identifiers

PMID37098612
PMCPMC10127414

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.