ArticleBMC psychiatry2023
Decreased gray matter volume and dynamic functional alterations in medicine-free obsessive-compulsive disorder.
Article in BMC psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Altered seed-to-whole-brain functional connectivity of goal-directed/habitual systems in obsessive-compulsive disorder: associated genes and preliminary classification potential.European archives of psychiatry and clinical neuroscience · 2026Article
- Functional connectivity changes in obsessive-compulsive disorder following exposure and response prevention.Translational psychiatry · 2026Article
- Genetic and molecular factors associated with changes in structural-functional coupling in medication-free obsessive-compulsive disorder.Psychological medicine · 2026Article
- Diagnosis of adolescent depression with sleep disorder based on network topological attributes and functional connectivity.BMC psychiatry · 2025Article
- Exploring connectivity and volume alterations in the Pulvinar's subnuclei: insights into the neuropathological role in obsessive-compulsive disorder (OCD).Psychological medicine · 2025Article
- Obsessive-compulsive disorder and temporal lobe porencephaly: a case report.BMC psychiatry · 2025Article
- Abnormal static and dynamic functional connectivity of striatal subregions in patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2025Article
- Unraveling the brain dynamics of Depersonalization-Derealization Disorder: a dynamic functional network connectivity analysis.BMC psychiatry · 2024Article
- Altered dynamic neural activities in individuals with obsessive-compulsive disorder and comorbid depressive symptoms.Frontiers in psychiatry · 2024Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies discovered the presence of abnormal structures and functions in the brain regions of patients with obsessive-compulsive disorder (OCD). Nevertheless, whether structural changes in brain regions are coupled with alterations in dynamic functional connectivity (dFC) at rest in medicine-free patients with OCD remains vague.
methodsThree-dimensional T
resultsOur findings indicated that GMV in the left superior temporal gyrus (STG) and right supplementary motor area (SMA) was reduced in OCD, and the dFC between the left STG and the left cerebellum Crus I and left thalamus, and between the right SMA and right dorsolateral prefrontal cortex (DLPFC) and left precuneus was decreased at rest in OCD. The brain regions both with altered GMV and dFC values could discriminate OCD from HCs with the accuracy of 0.85, sensitivity of 0.90 and specificity of 0.80.
conclusionThe decreased gray matter structure coupling with dynamic function in the left STG and right SMA at rest may be crucial in the pathophysiology of OCD.
trial registrationStudy on the mechanism of brain network in obsessive-compulsive disorder with multi-model magnetic resonance imaging (registration date: 08/11/2017; registration number: ChiCTR-COC-17,013,301).
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