Evidence map›Paper›PMID 37098324›Full record

ArticleDevelopmental cell2023

The beauty of seeing the real thing: BMP heterodimer detection in vivo reveals dimer composition and activity.

Giovanna M Collu, Marek Mlodzik

Abstract readComment
In one paragraph

Article in Developmental cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Giovanna M ColluDepartment of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Marek MlodzikDepartment of Cell, Developmental, and Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: marek.mlodzik@mssm.edu.

Funding

Retinal Patterning During Eye DevelopmentR01EY013256 · NEI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Marek Mlodzik · 2001 to 2026
$10.0M
Wnt/Frizzled-PCP signaling in development and diseaseR35GM127103 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Marek Mlodzik · 2018 to 2026
$5.6M
NEI NIH HHS R01 EY013256NIGMS NIH HHS R35 GM127103
6 · The paper itself

Abstract

BMP family ligands can direct cells to divide, differentiate, or die, depending on cell context and specific hetero- or homodimer combinations. In this issue of Developmental Cell, Bauer et al. detect endogenous Drosophila ligand dimers in situ and show that BMP dimer composition affects both signaling range and activity.

Indexed as

Bone Morphogenetic ProteinsDrosophila ProteinsAnimalsDrosophilaLigandsSignal TransductionBone Morphogenetic ProteinsDrosophila ProteinsLigands

Identifiers

PMID37098324
PMCPMC11288136

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.