Evidence map›Paper›PMID 37098109›Full record

ReviewImmunological reviews2023

Senescent T cells: Beneficial and detrimental roles.

Phatthamon Laphanuwat, Daniel Claudio Oliveira Gomes, Arne N Akbar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunological reviews, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Targeting the CD4Molecular biomedicine · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Loss of LXRβ Drives CD4Biomedicines · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Phatthamon LaphanuwatDivision of Medicine, University College London, London, UK.ORCID 0000-0001-7778-0031
Daniel Claudio Oliveira GomesDivision of Medicine, University College London, London, UK.
Arne N AkbarDivision of Medicine, University College London, London, UK.

Funding

Medical Research Council MR/P00184X/1Medical Research Council MR/T015853/1Medical Research Council MR/T030534/1
6 · The paper itself

Abstract

As the thymus involutes during aging, the T-cell pool has to be maintained by the periodic expansion of preexisting T cells during adulthood. A conundrum is that repeated episodes of activation and proliferation drive the differentiation of T cells toward replicative senescence, due to telomere erosion. This review discusses mechanisms that regulate the end-stage differentiation (senescence) of T cells. Although these cells, within both CD4 and CD8 compartments, lose proliferative activity after antigen-specific challenge, they acquire innate-like immune function. While this may confer broad immune protection during aging, these senescent T cells may also cause immunopathology, especially in the context of excessive inflammation in tissue microenvironments.

Indexed as

Cellular SenescenceT-LymphocytesAdultAgingAntigensCD8-Positive T-LymphocytesCell DifferentiationHumansAntigensagingsenescenceT cellTEMRAterminally differentiated cell

Identifiers

PMID37098109
PMCPMC10952287

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.