Evidence map›Paper›PMID 37098070›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Identification of small-molecule protein-protein interaction inhibitors for NKG2D.

Aaron A Thompson, Michael B Harbut, Pei-Pei Kung, Nathan K Karpowich, Jeffrey D Branson, Joanna C Grant, Deborah Hagan, Heather A Pascual, Guoyun Bai, Reza Beheshti Zavareh and 30 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Secondary Sites of the C-type Lectin-Like Fold.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors at 1 institution in 1 country.

Aaron A ThompsonTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0003-4314-4242
Michael B HarbutTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Pei-Pei KungTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0002-9203-7374
Nathan K KarpowichTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Jeffrey D BransonTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Joanna C GrantTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Deborah HaganTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Heather A PascualTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Guoyun BaiTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Reza Beheshti ZavarehTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0002-3345-408X
Heather R CoateTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Bernard C CollinsTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Marjorie CôteTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Christine F GelinTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Kelly L Damm-GanametTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0001-6377-8280
Hadi GholamiTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Adam R HuffTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Luis LimonTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Kevin J LumbTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Puiying A MakTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Kohki M NakafukuTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0003-1246-1325
Edmund V PriceTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Amy Y ShihTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Mandana TootoonchiDiscovery Immunology, Janssen Research & Development, San Diego, CA 92121.
Nadeem A VelloreTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0009-0009-0067-1588
Jocelyn WangTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Na WeiTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Jeannie ZiffTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0002-5406-6713
Scott B BergerDiscovery Immunology, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
James P EdwardsTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Agnès GardetDiscovery Immunology, Janssen Research & Development, San Diego, CA 92121.ORCID 0000-0002-8168-1834
Siquan SunDiscovery Immunology, Janssen Research & Development, San Diego, CA 92121.
Jennifer E TowneDiscovery Immunology, Janssen Research & Development, San Diego, CA 92121.
Jennifer D VenableTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Zhicai ShiTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Hariharan VenkatesanTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Marie-Laure RivesTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Sujata SharmaTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.
Brock T ShiremanTherapeutics Discovery, Janssen Research & Development, San Diego, CA 92121.
Samantha J AllenTherapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.ORCID 0000-0002-2384-1924
Janssen (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NKG2D (natural-killer group 2, member D) is a homodimeric transmembrane receptor that plays an important role in NK, γδ

Indexed as

Killer Cells, NaturalNK Cell Lectin-Like Receptor Subfamily KCD8-Positive T-LymphocytesLigandsProtein BindingLigandsNK Cell Lectin-Like Receptor Subfamily KDNA-encoded library screeninginflammationNKG2Dprotein–protein interaction

Identifiers

PMID37098070
PMCPMC10160951
OpenAlexW4366981271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.