ArticleProceedings of the National Academy of Sciences of the United States of America2023
Comparative connectomics reveals noncanonical wiring for color vision in human foveal retina.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Synaptic Organization of the Primate Retina: Toward a Human Foveal Connectome.Annual review of vision science · 2026Review
- Approaching a connectome of the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- An image-computable spatio-chromatic receptive field model of the midget retinal ganglion cell mosaic across the retina.Journal of computational neuroscience · 2026Article
- Connectome of a human foveal retina.bioRxiv : the preprint server for biology · 2026Article
- S-cone-specific circuitry in the outer plexiform layer of a cone-dominant mammal.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Local variations in L/M ratio influence the detection and color naming of small spots.Journal of vision · 2025Article
- Local variations in L/M ratio influence the detection and color naming of small spots.bioRxiv : the preprint server for biology · 2025Article
- Electroretinographic responses to periodic stimuli in primates and the relevance for visual perception and for clinical studies.Visual neuroscience · 2024Review
- A circuit motif for color in the human foveal retina.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Unique yellow shifts for small and brief stimuli in the central retina.Journal of vision · 2024Article
- Cone-Opponent Ganglion Cells in the Primate Fovea Tuned to Noncardinal Color Directions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Evolutionary and developmental specialization of foveal cell types in the marmoset.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Docosahexaenoic Acid Explains the Unexplained in Visual Transduction.Entropy (Basel, Switzerland) · 2023Article
- Losing, preserving, and restoring vision from neurodegeneration in the eye.Current biology : CB · 2023Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The Old World macaque monkey and New World common marmoset provide fundamental models for human visual processing, yet the human ancestral lineage diverged from these monkey lineages over 25 Mya. We therefore asked whether fine-scale synaptic wiring in the nervous system is preserved across these three primate families, despite long periods of independent evolution. We applied connectomic electron microscopy to the specialized foveal retina where circuits for highest acuity and color vision reside. Synaptic motifs arising from the cone photoreceptor type sensitive to short (S) wavelengths and associated with "blue-yellow" (S-ON and S-OFF) color-coding circuitry were reconstructed. We found that distinctive circuitry arises from S cones for each of the three species. The S cones contacted neighboring L and M (long- and middle-wavelength sensitive) cones in humans, but such contacts were rare or absent in macaques and marmosets. We discovered a major S-OFF pathway in the human retina and established its absence in marmosets. Further, the S-ON and S-OFF chromatic pathways make excitatory-type synaptic contacts with L and M cone types in humans, but not in macaques or marmosets. Our results predict that early-stage chromatic signals are distinct in the human retina and imply that solving the human connectome at the nanoscale level of synaptic wiring will be critical for fully understanding the neural basis of human color vision.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.