ArticleProceedings of the National Academy of Sciences of the United States of America2023
Parvalbumin interneuron activity drives fast inhibition-induced vasoconstriction followed by slow substance P-mediated vasodilation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular alterations in chondrolectin-containing somatostatin neurons in schizophrenia differ based on circuit context.Molecular psychiatry · 2026Article
- Parvalbumin interneurons contribute to spontaneous hemodynamic fluctuations.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026Article
- Substance P regulates Tacr1 neurons, which control nitric oxide-mediated neurovascular coupling in the mouse cortex.Science advances · 2026Article
- Resting fMRI functional connectivity reflects fluctuations in inhibitory interneuron activity.bioRxiv : the preprint server for biology · 2026Article
- Cortex-specific inversion of visual responses during sleep.Nature communications · 2026Article
- Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI.Neuroscience bulletin · 2026Article
- The neurovascular impulse response function differentially reflects intrinsic neuromodulation across cortical regions.Nature neuroscience · 2026Article
- Orbitofrontal PV interneurons modulate social interaction via default mode network dynamics.Communications biology · 2026Article
- BOLD response delays represent local cortical processing.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Cortex-specific inversion of visual responses during sleep.bioRxiv : the preprint server for biology · 2026Article
- Assessing chance in neuro-vascular interactions.NeuroImage · 2026Article
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- Psychedelic 5-HTNature neuroscience · 2025Article
- Interhemispheric resting-state functional connectivity correlates with spontaneous neural interactions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Somatostatin-expressing interneurons induce early NO-driven and late specific astrocyte-mediated vasodilation.Nature communications · 2025Article
- Type-I nNOS neurons orchestrate cortical neural activity and vasomotion.bioRxiv : the preprint server for biology · 2025Article
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- Correlation of zero echo time functional MRI with neuronal activity in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2025Article
- Neuromodulation in Small Animal fMRI.Journal of magnetic resonance imaging : JMRI · 2025Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of parvalbumin (PV) interneurons in vascular control is poorly understood. Here, we investigated the hemodynamic responses elicited by optogenetic stimulation of PV interneurons using electrophysiology, functional magnetic resonance imaging (fMRI), wide-field optical imaging (OIS), and pharmacological applications. As a control, forepaw stimulation was used. Stimulation of PV interneurons in the somatosensory cortex evoked a biphasic fMRI response in the photostimulation site and negative fMRI signals in projection regions. Activation of PV neurons engaged two separable neurovascular mechanisms in the stimulation site. First, an early vasoconstrictive response caused by the PV-driven inhibition is sensitive to the brain state affected by anesthesia or wakefulness. Second, a later ultraslow vasodilation lasting a minute is closely dependent on the sum of interneuron multiunit activities, but is not due to increased metabolism, neural or vascular rebound, or increased glial activity. The ultraslow response is mediated by neuropeptide substance P (SP) released from PV neurons under anesthesia, but disappears during wakefulness, suggesting that SP signaling is important for vascular regulation during sleep. Our findings provide a comprehensive perspective about the role of PV neurons in controlling the vascular response.
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