Evidence map›Paper›PMID 37097595›Full record

ArticleJournal of neurovirology2023

Detection of human neurotropic JCPyV DNA sequence in pediatric anaplastic xanthoastrocytoma.

Sara Passerini, Carla Prezioso, Annalisa Prota, Giulia Babini, Lavinia Bargiacchi, Daniela Bartolini, Ugo Moens, Manila Antonelli, Valeria Pietropaolo

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Sara PasseriniDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, P.1e Aldo Moro, 5, 00185, Rome, Italy.
Carla PreziosoLaboratory of Microbiology of Chronic-Neurodegenerative Diseases, IRCCS San Raffaele Roma, Rome, Italy.
Annalisa ProtaDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, P.1e Aldo Moro, 5, 00185, Rome, Italy.
Giulia BabiniDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, P.1e Aldo Moro, 5, 00185, Rome, Italy.
Lavinia BargiacchiDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
Daniela BartoliniPathology Unit, Bufalini Hospital, Cesena, Italy.
Ugo MoensDepartment of Medical Biology, Faculty of Health Sciences, University of Tromsø, The Arctic University of Norway, Tromsø, Norway.
Manila AntonelliDepartment of Radiological, Oncological and Anatomo-Pathological Sciences, "Sapienza" University of Rome, Rome, Italy.
Valeria PietropaoloDepartment of Public Health and Infectious Diseases, "Sapienza" University of Rome, P.1e Aldo Moro, 5, 00185, Rome, Italy. valeria.pietropaolo@uniroma1.it.ORCID 0000-0001-5723-8886
Department of Public Health · MMSapienza University of Rome · ITOspedale “M. Bufalini” di Cesena · ITUiT The Arctic University of Norway · NOVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Due to its peculiar histopathological findings, pleomorphic xanthoastrocytoma (PXA), a rare cerebral tumor of young adults with a slow growth and a good prognosis, resembles to the lytic phase of progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease caused by JC polyomavirus (JCPyV). Therefore, the presence of JCPyV DNA was examined in an 11-year-old child with xanthoastrocytoma, WHO grade 3, by quantitative PCR (qPCR) and nested PCR (nPCR) using primers amplifying sequences encoding the N- and C-terminal region of large T antigen (LTAg), the non-coding control region (NCCR), and viral protein 1 (VP1) DNA. The expression of transcripts from LTAg and VP1 genes was also evaluated. In addition, viral microRNAs' (miRNAs) expression was investigated. Cellular p53 was also searched at both DNA and RNA level. qPCR revealed the presence of JCPyV DNA with a mean value of 6.0 × 10

Indexed as

JC VirusLeukoencephalopathy, Progressive MultifocalMicroRNAsNeurodegenerative DiseasesAntigens, Viral, TumorBase SequenceChildDNA, ViralHumansTumor Suppressor Protein p53Young AdultAntigens, Viral, TumorDNA, ViralMicroRNAsTumor Suppressor Protein p53JCPyVLTAgNCCRRbTransformationXanthoastrocytoma

Identifiers

PMID37097595
PMCPMC10185596
OpenAlexW4366983753

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.