Evidence map›Paper›PMID 37097586›Full record

ArticleJournal of ophthalmic inflammation and infection2023

Incidence and clinical characteristic of ocular surface manifestation: an evaluation of conjunctival swab results in Corona Virus 2019 (COVID-19) patients in Jakarta, Indonesia.

Made Susiyanti, Hisar Daniel, Diah Faridah, Dinda Arken Devona, Pradnya Pramitha, Budiman Bela, Budi Haryanto, Julie Dewi Barliana, Dian Estu, Andi Arus Victor and 4 more

Abstract read
In one paragraph

Article in Journal of ophthalmic inflammation and infection, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Made SusiyantiDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Hisar DanielDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Diah FaridahDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia.
Dinda Arken DevonaDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia.
Pradnya PramithaDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia.
Budiman BelaDepartment of Clinical Microbiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Budi HaryantoDepartment of Clinical Microbiology, Faculty of Medicine Universitas Indonesia, Persahabatan Hospital, Jakarta, Indonesia.
Julie Dewi BarlianaDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Dian EstuDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Andi Arus VictorDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Nina Dwi PutriDepartment of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia.
Julius CandraDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Nathania SutandiDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia.
Rita S SitorusDepartment of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jalan Kimia No. 8-10, Jakarta, 10320, Indonesia. ritasito@yahoo.com.

Funding

PUTI Saintekes Grant by University of Indonesia NKB-2300/UN2.RST/HKP.05.00/2020
6 · The paper itself

Abstract

objectivesThis study aimed to investigate the spectrum of ocular characteristics and viral presence in the conjunctival swab of patients with COVID-19.

methodsIn this cross-sectional study, fifty-three patients were recruited from two COVID-19 referral hospitals in Jakarta (Cipto Mangunkusumo Hospital and Persahabatan Hospital) from July 2020 to March 2021. The inclusion criteria were patients who were suspected of or confirmed cases of COVID-19 with or without ocular symptoms. Demographic data, history of COVID-19 exposure, underlying medical condition, systemic symptoms, ocular symptoms, supporting laboratory results, reverse-transcriptase polymerase chain reaction (RT-PCR) of naso-oropharyngeal (NOP) swab and conjunctival swab were collected.

resultsFifty-three patients who were suspected, probable or confirmed cases of Covid-19 were included. Forty-six out of 53 patients (86.79%) tested positive for either Covid-19 antibody rapid test or naso-oropharyngeal (NOP) swab. Forty-two patients tested positive for NOP swab. Fourteen out of 42 patients (33.33%) experienced symptoms of ocular infection including red eye, epiphora, itchy eyes, and eye discharge. None of these patients were tested positive for conjunctival swab. Two out of 42 patients (4.76%), who were tested positive for conjunctival swab, did not experience any ocular symptoms.

conclusionsEstablishing the relationship between Covid-19 infection, ocular symptoms, and presence of SARS-CoV-2 virus on the ocular surface proves to be challenging. In Covid-19 patients, ocular symptoms did not warrant a positive conjunctival swab result. On the contrary, a patient without ocular symptoms can also have detectable presence of SARS-CoV-2 virus on the ocular surface.

Indexed as

Conjunctival swabCOVID-19Ocular manifestation

Identifiers

PMID37097586
PMCPMC10127182

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.