ArticleThe Journal of experimental medicine2023
Depleting CD103+ resident memory T cells in vivo reveals immunostimulatory functions in oral mucosa.
Article in The Journal of experimental medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Pregnancy-induced tissue-resident memory-like T cells contribute to tumor control in breast cancer.Nature immunology · 2026Article
- CD69 Regulates Gingival Inflammation and Microbiome in Periodontitis.Journal of dental research · 2026Article
- Harnessing mucosal immunity for protective vaccines.Nature reviews. Immunology · 2026Review
- Repeated intravesical platelet-rich plasma injections alleviate symptoms via T-cell modulation and mitochondrial dysfunction in non-ulcer interstitial cystitis/bladder pain syndrome.Scientific reports · 2026Article
- Evolving role of CD8Frontiers in immunology · 2026Review
- Mucosal immune cell priming by intranasally deliveredFrontiers in immunology · 2026Article
- Remodeling mechanisms and intervention strategies of the oral mucosal immune barrier.Frontiers in immunology · 2026Review
- Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design.Nature reviews. Immunology · 2025Review
- Triggering mouth-resident antiviral CD8Mucosal immunology · 2025Article
- Integration of Single-Cell RNA Sequencing Data and Bulk Sequencing Data to Characterise the CD8+ T-Cell Exhaustion Mediated Immune Microenvironment in CRC.Journal of cellular and molecular medicine · 2025Article
- Integrating natural commensals and pathogens into preclinical mouse models.Nature reviews. Immunology · 2025Review
- Viral infection and antiviral immunity in the oral cavity.Nature reviews. Immunology · 2025Review
- Tissue-resident memory T cells in urinary tract diseases.Frontiers in immunology · 2025Review
- Gingival spatial analysis reveals geographic immunological variation in a microbiota-dependent and -independent manner.NPJ biofilms and microbiomes · 2024Article
- Resident memory T cells and cancer.Immunity · 2024Review
- Differential Contributions of Interferon Classes to Host Inflammatory Responses and Restricting Virus Progeny Production.Journal of proteome research · 2024Article
- Resident memory T cells in dirty mice suppress innate cell activation and infiltration into the skin following stimulation with alarmins.bioRxiv : the preprint server for biology · 2024Article
- CD8+ Tissue-Resident Memory T Cells: Versatile Guardians of the Tissue.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- CD115Cell reports · 2023Article
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Authors and funding
15 authors.
Funding
Abstract
The oral mucosa is a frontline for microbial exposure and juxtaposes several unique tissues and mechanical structures. Based on parabiotic surgery of mice receiving systemic viral infections or co-housing with microbially diverse pet shop mice, we report that the oral mucosa harbors CD8+ CD103+ resident memory T cells (TRM), which locally survey tissues without recirculating. Oral antigen re-encounter during the effector phase of immune responses potentiated TRM establishment within tongue, gums, palate, and cheek. Upon reactivation, oral TRM triggered changes in somatosensory and innate immune gene expression. We developed in vivo methods for depleting CD103+ TRM while sparing CD103neg TRM and recirculating cells. This revealed that CD103+ TRM were responsible for inducing local gene expression changes. Oral TRM putatively protected against local viral infection. This study provides methods for generating, assessing, and in vivo depleting oral TRM, documents their distribution throughout the oral mucosa, and provides evidence that TRM confer protection and trigger responses in oral physiology and innate immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.