ArticleRadiology2023
Predicting Microvascular Invasion in Hepatocellular Carcinoma Using CT-based Radiomics Model.
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Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 4 of them syntheses that pooled it.
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147citing papers in PubMed, 4 pooled it
46.8field-weighted citation impact, top 1% of its field
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Who cites it
147 citing papers in PubMed, 4 syntheses or guidelines pooled it, 202 citations in OpenAlex.
- Computed tomography-based artificial intelligence for predicting preoperative microvascular invasion in hepatocellular carcinoma: a systematic review and meta-analysis.La Radiologia medica · 2026Pooled it
- Pooled it
- Preoperative prediction power of radiomics and non-radiomics methods based on MRI for early recurrence in hepatocellular carcinoma: a systemic review and meta-analysis.Abdominal radiology (New York) · 2024Pooled it
- Radiomics as a tool for prognostic prediction in transarterial chemoembolization for hepatocellular carcinoma: a systematic review and meta-analysis.La Radiologia medica · 2024Pooled it
- Early hemodynamic assessment and longitudinal imaging for predicting graft outcomes post-transplant.Annals of medicine · 2026Article
- Advances in liver transplantation for hepatic malignancies.Hepatic oncology · 2026Review
- Decoding tumor heterogeneity with imaging biomarkers predicts response to TACE plus immunotherapy and targeted therapy in HCC (CHANCE2204).Hepatology (Baltimore, Md.) · 2026Article
- Molecular biomarkers for diagnosis, prognosis, precision therapy, and immunotherapy in cholangiocarcinoma, cHCC-CCA, and HCC.Hepatology communications · 2026Review
- A preoperative model for predicting microvascular invasion in hepatocellular carcinoma based on laboratory findings and MRI features.Updates in surgery · 2026Article
- Artificial intelligence in hepatocellular carcinoma diagnosis and AI-assisted treatment support: Current landscape and future directions.Liver research (Beijing, China) · 2026Review
- Non-Invasive Assessment of Microvascular Invasion Risk in Hepatocellular Carcinoma Using Liquid Biopsy: Translational Insights and Clinical Implications.Diagnostics (Basel, Switzerland) · 2026Review
- Noninvasive Multi-Omics Radiomic Model Integrating scRNA-seq and Bulk RNA-seq for Hepatocellular Carcinoma Prognosis.Journal of imaging informatics in medicine · 2026Article
- Preoperative MRI Intratumoral Heterogeneity Radiomics for Microvascular Invasion and Recurrence-Free Survival in HCC.Liver international : official journal of the International Association for the Study of the Liver · 2026Observational
- Intratumor habitat aware deep learning framework for preoperative lymph node metastasis prediction in laryngeal carcinoma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Development of multiphasic CT-based delta-radiomics model for predicting postoperative recurrence risk in bladder cancer.BMC medical imaging · 2026Article
- Radiologic exposomics: imaging the environmental imprint on cancer for precision oncology.La Radiologia medica · 2026Review
- Prediction of Ki-67 expression in hepatocellular carcinoma: a dual-center study based on T2-weighted imaging habitat analysis.Radiology and oncology · 2026Article
- Hybrid imaging-clinical model for predicting microvascular invasion in hepatocellular carcinoma using deep learning-derived features from CT.Physical and engineering sciences in medicine · 2026Article
- Clustering of quantitative CT features identifies HCC subtypes with distinct prognosis and immune signatures.European radiology experimental · 2026Article
- Quantitative analysis of enhanced CT in predicting microvascular invasion and pathological grading of hepatocellular carcinoma.European radiology · 2026Article
87 more citing papers are in PubMed but not listed here.
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Authors and funding
15 authors at 1 institution in 1 country.
Tian-Yi XiaFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-9341-7742
Zheng-Hao ZhouFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0003-3668-3993
Xiang-Pan MengFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0002-2917-2418
Jun-Hao ZhaFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-8166-4949
Qian YuFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-5068-6854
Wei-Lang WangFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-5067-6859
Yang SongFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-7426-4496
Yuan-Cheng WangFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0002-6253-8311
Tian-Yu TangFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-5463-8008
Jun XuFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0003-4721-9045
Tao ZhangFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0002-4493-7220
Xue-Ying LongFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0002-3457-4147
Yun LiangFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0002-2631-6172
Wen-Bo XiaoFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-7124-1096
Sheng-Hong JuFrom the Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, School of Medicine, Southeast University, 87 Ding Jia Qiao Road, Nanjing, China 210009 (T.Y.X., X.P.M., J.H.Z., Q.Y., W.L.W., Y.C.W., T.Y.T., S.H.J.); Institute for AI in Medicine, School of Artificial Intelligence, Nanjing University of Information Science and Technology, Nanjing, China (Z.H.Z., J.X.); MR Scientific Marketing, Siemens Healthineers, Shanghai, China (Y.S.); Department of Radiology, The Third Affiliated Hospital of Nantong University, Nantong, China (T.Z.); Department of Radiology, The Xiangya Hospital of Central South University, Changsha, China (X.Y.L.); Department of Radiology, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, China (Y.L.); and Department of Radiology, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China (W.B.X.).ORCID 0000-0001-5041-7865
Central South University · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Prediction of microvascular invasion (MVI) may help determine treatment strategies for hepatocellular carcinoma (HCC). Purpose To develop a radiomics approach for predicting MVI status based on preoperative multiphase CT images and to identify MVI-associated differentially expressed genes. Materials and Methods Patients with pathologically proven HCC from May 2012 to September 2020 were retrospectively included from four medical centers. Radiomics features were extracted from tumors and peritumor regions on preoperative registration or subtraction CT images. In the training set, these features were used to build five radiomics models via logistic regression after feature reduction. The models were tested using internal and external test sets against a pathologic reference standard to calculate area under the receiver operating characteristic curve (AUC). The optimal AUC radiomics model and clinical-radiologic characteristics were combined to build the hybrid model. The log-rank test was used in the outcome cohort (Kunming center) to analyze early recurrence-free survival and overall survival based on high versus low model-derived score. RNA sequencing data from The Cancer Image Archive were used for gene expression analysis. Results A total of 773 patients (median age, 59 years; IQR, 49-64 years; 633 men) were divided into the training set (
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Carcinoma, HepatocellularLiver NeoplasmsHumansMaleMiddle AgedNeoplasm InvasivenessRetrospective StudiesTomography, X-Ray Computed
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