ArticlePsychiatry and clinical neurosciences2023
Gray matter reserve determines glymphatic system function in young-onset Alzheimer's disease: Evidenced by DTI-ALPS and compared with age-matched controls.
Article in Psychiatry and clinical neurosciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 3 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Glymphatic dysfunction in Alzheimer's disease: a systematic review and meta-analysis of the DTI-ALPS index as an imaging biomarker.Frontiers in aging neuroscience · 2026Pooled it
- Imaging biomarkers of glymphatic system dysfunction in Alzheimer's disease: a systematic review and meta-analysis with a focus on DTI-ALPS index.Frontiers in aging neuroscience · 2026Pooled it
- Evaluating the robustness of DTI-ALPS in clinical context: a meta-analytic parallel on Alzheimer's and Parkinson's diseases.Scientific reports · 2024Pooled it
- Exploring the role of glymphatic system in Alzheimer's disease with insights from MRI-based studies: a systematic review.Neuroradiology · 2026Review
- Change in Amyloid-β Deposition and Diffusion Tensor Image Analysis along the Perivascular Space Index in Incident Neurodegenerative Disease.Annals of neurology · 2026Article
- Reduced glymphatic function in autism revealed by the diffusion tensor analysis along the perivascular space index.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Hierarchical organization of tau topography across the Alzheimer's disease continuum integrates amyloid, connectome, and intrinsic molecular vulnerability.Communications biology · 2026Article
- Genetic variation in the glymphatic pathway predicts cognition and neurodegeneration in preclinical Alzheimer's disease.Research square · 2026Article
- Impaired glymphatic function is associated with synaptic loss in cognitive impairment.European journal of nuclear medicine and molecular imaging · 2026Article
- Associations among MRI-derived glymphatic system impairment, gray matter reserve and white matter integrity in cerebral small-vessel disease patients.Brain imaging and behavior · 2026Article
- Gray matter atrophy mediated the association between glymphatic function and cognition in Alzheimer's disease: a multicenter DTI-ALPS study.BMC medical imaging · 2026Article
- Deep gray matter atrophy mediates the associations between glymphatic dysfunction and clinical disability in relapsing-remitting multiple sclerosis: a neuroimaging subgroup study.Frontiers in immunology · 2026Article
- Multiple system atrophy: advances in pathogenesis and emerging therapeutic strategies.Journal of neurology · 2025Review
- MRI-based surrogates of brain clearance in narcolepsy type 1.Journal of sleep research · 2025Article
- Impaired glymphatic function in relation to cumulative blood glucose exposure: A population-based cohort study.IBRO neuroscience reports · 2025Article
- Glymphatic system dysfunction mediates amyloid deposition and cognitive impairment in Alzheimer's disease: a PET/MRI multimodality imaging study.EJNMMI research · 2025Article
- Impaired Glymphatic Clearance, Measured Using Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS), is Linked to Poor Cognitive Outcomes in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients.The European journal of neuroscience · 2025Article
- Hemodialysis and its effects on glymphatic system function in end-stage kidney disease patients.Quantitative imaging in medicine and surgery · 2025Article
- Glymphatic alteration in NAFLD patient: a preliminary magnetic resonance imaging study based on DTI-ALPS.BMC psychiatry · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundThe diffusion tensor imaging analysis along the perivascular space (ALPS)-index can be used to model the glymphatic system in vivo.
aimThis study explores putative mechanisms between prediction of ALPS-index and cognitive outcomes in young-onset Alzheimer's disease (YOAD) and age-matched controls (CTLs) and analyzes whether the link was mediated by the integrity of ALPS-index-anchored cerebral gray matter (GM).
methodsWe enrolled 130 patients with YOAD and 137 CTLs. All participants underwent three-dimensional T
resultsPatient group had significantly lower ALPS-index. The ALPS-index was associated with GM volume in the cerebellar gray, dorsolateral prefrontal, thalamus, superior frontal, amygdala and hippocampus, and these coherent regions coincided with those showing GM atrophy in the YOAD group. Mediation analysis of the YOAD group suggested that the relationships between the ALPS-index and cognitive performance were fully mediated by the integrity of ALPS-index coherent GM areas. DISCUSSION: Reserved GM mediates the link between the glymphatic system and cognition. Our findings suggest that GM integrity rather than the glymphatic system could serve as a direct cognitive test scores predictor in patients with YOAD.
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