Evidence map›Paper›PMID 37096953›Full record

ArticleCancer medicine2023

Identification of optimal primary tumor resection candidates for metastatic gastric cancer: Nomograms based on propensity score matching.

Zhehong Li, Honghong Zheng, Ziming Zhao, Guanyang Chen, Zheng Wang, Buhe Amin, Nengwei Zhang

Abstract read
In one paragraph

Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhehong LiDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-9385-0618
Honghong ZhengDepartment of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
Ziming ZhaoDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Guanyang ChenDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Zheng WangDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Buhe AminDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.
Nengwei ZhangDepartment of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study sought to develop and validate nomograms for screening patients with metastatic gastric cancer (mGC) who are candidates for primary tumor resection (PTR) and evaluating the prognosis of mGC patients after PTR.

methodsFrom 2010 to 2016, we screened mGC patients with complete data from the Surveillance, Epidemiology, and End Results (SEER) database. Depending on whether or not PTR was performed, we categorized patients into surgery and non-surgery groups. A 1:1 propensity score matching (PSM) analysis was used to balance the characteristics of the two groups. The endpoints were overall survival (OS) and cancer-specific survival (CSS). Two predictive nomograms were developed using logistic regression to assess the likelihood of benefit. Two additional prognostic nomograms were developed to assess prognosis in mGC patients after PTR by Cox regression. Finally, nomograms were evaluated using a variety of methodologies.

resultsOur study included 3594 mGC patients who met the criteria. PTR was associated with improved OS and CSS time (median OS time after PSM: 15 vs. 7 months, P < 0.05; median CSS time after PSM: 17 vs. 7 months, P < 0.05). The OS-related predictive nomogram, including age, histologic type, grade, T stage, and chemotherapy, was developed. Moreover, the CSS-related predictive nomogram, including age, histologic type, grade, and chemotherapy, was developed. Sex, histologic type, grade, T stage, N stage, and chemotherapy were found to be correlated with OS. Furthermore, the CSS correlated with histologic type, grade, T stage, N stage, and chemotherapy. Both predictive and prognostic nomograms were found to be valuable and reliable after different types of validation.

conclusionPredictive nomograms were developed and validated for identifying the optimal PTR mGC candidates. Prognostic nomograms were developed and validated for assessing the prognosis of mGC patients after PTR.

Indexed as

Splenic NeoplasmsStomach NeoplasmsDatabases, FactualHumansNomogramsPrognosisPropensity ScoreSEER ProgramMetastatic gastric cancernomogramprimary tumor resectionpropensity score matchingsurgerythe SEER database

Identifiers

PMID37096953
PMCPMC10315800

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